Isoquinoline-1-carbonyl chloride

Base Information

• Chemical Name: Isoquinoline-1-carbonyl chloride
• CAS No.: 180411-55-6
• Molecular Formula: C10H6ClNO
• Molecular Weight: 191.61400
• Mol file: 180411-55-6.mol

Synonyms:isoquinoline-1-carboxylic acid chloride;Isoquinoline-1-carbonyl chloride;isoquinolinecarbonyl chloride;1-isoquinolinecarbonyl chloride;

Chemical Property of Isoquinoline-1-carbonyl chloride

Chemical Property:

• PSA: 29.96000
• LogP: 2.61380

Purity/Quality:

99%, ^*data from raw suppliers

Isoquinoline-1-carbonyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoquinoline-1-carbonyl chloride

There total 1 articles about Isoquinoline-1-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-isoquinolinecarboxylic acid (486-73-7) → 1-isoquinolinecarbonyl chloride (180411-55-6)

Guidance literature:

With oxalyl dichloride;

DOI:10.1016/0040-4039(91)80063-C

Reference yield: 72.0%

tert-butyl (S)-4,4-diethoxy-3-((1R,2R)-2-(1-isopropylhydrazine-1-carbonyl)cyclohexane-1-carboxamido)butanoate + 1-isoquinolinecarbonyl chloride (180411-55-6) → tert-butyl (S)-4,4-diethoxy-3-((1R,2R)-2-(1-isopropyl-2-(isoquinoline-1-carbonyl)hydrazine-1-carbonyl)cyclohexane-1-carboxamido)butanoate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.8b00067

Reference yield:

2(R,S)-(2-amino-benzoylamino)-3-phenyl-propionic acid ethyl ester (32771-73-6) + 1-isoquinolinecarbonyl chloride (180411-55-6) → 2(RS)-{2-[(isoquinoline-1-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic acid ethyl ester (685141-88-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2003.11.010

upstream raw materials:

1-isoquinolinecarboxylic acid

Downstream raw materials:

2(RS)-{2-[(isoquinoline-1-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic acid ethyl ester

(E)-2-(2-(2-fluorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl isoquinoline-1-carboxylate

(E)-2-(5-nitro-2-(2-nitrostyryl)-1H-imidazol-1-yl)ethyl isoquinoline-1-carboxylate

(E)-2-(5-nitro-2-(3-nitrostyryl)-1H-imidazol-1-yl)ethyl isoquinoline-1-carboxylate

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