(5-chloro-2-methoxyphenyl)methanamine

Base Information

• Chemical Name: (5-chloro-2-methoxyphenyl)methanamine
• CAS No.: 181473-92-7
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Hs Code.: 2922299090
• Mol file: 181473-92-7.mol

Synonyms:5-Chloro-2-methoxybenzylamine;Benzenemethanamine,5-chloro-2-methoxy;

Chemical Property of (5-chloro-2-methoxyphenyl)methanamine

Chemical Property:

• Boiling Point: 252.8±25.0 °C(Predicted)
• PKA: 8.86±0.10(Predicted)
• PSA: 35.25000
• Density: 1.180±0.06 g/cm3(Predicted)
• LogP: 2.50760
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

(5-chloro-2-methoxyphenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-chloro-2-methoxyphenyl)methanamine

There total 2 articles about (5-chloro-2-methoxyphenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-methoxy-5-chlorobenzonitrile (55877-79-7) → 1-(5-chloro-2-methoxyphenyl)methanamine (181473-92-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 30 ℃; for 1.5h;

DOI:10.1016/j.ejmech.2012.06.050

Reference yield:

→ 1-(5-chloro-2-methoxyphenyl)methanamine (181473-92-7)

Guidance literature:

Reference yield: 78.0%

(2R,3R,4S)-2-(2,6-dichloro-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol (945457-82-9) + 1-(5-chloro-2-methoxyphenyl)methanamine (181473-92-7) → (2R,3R,4S)-2-(2-chloro-6-(5-chloro-2-methoxybenzylamino)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1021/jm070259t

upstream raw materials:

2-methoxy-5-chlorobenzonitrile

Downstream raw materials:

(1'S,2'R,3'S,4'R,5'S)-4'-[6-(5-chloro-2-methoxybenzylamino)-2-chloropurin-9-yl]-2',3'-O-isopropylidenebicyclo[3.1.0]haxane-1'-carboxylic acid ethyl ester

N-[(5-chloro-2-methoxyphenyl)methyl]methanesulfonamide

N-[(5-chloro-2-methoxyphenyl)methyl]-N'-(3-nitrophenyl)thiourea

N-[(5-chloro-2-methoxyphenyl)methyl]-N'-(4-nitrophenyl)thiourea

Refernces

• 1、 -. "2-substituted parazoleamino-4-substituted amino-5-pyrimidine formamide compound, composition and application thereof". Paragraph 0121-0122; 0129. . Retrieved 2019/04/10.
• 2、 -. "Compounds for the treatment of ischemia". Page 59. . Retrieved 2010/02/08.