55877-79-7

Usage

Uses

It is employed as an intermediate for pharmaceutical.

InChI:InChI=1/C8H6ClNO/c1-11-8-3-2-7(9)4-6(8)5-10/h2-4H,1H3

Upstream product

• 635-93-8 5-chlorosalicyclaldehyde 
• 7035-09-8 5-chloro-2-methoxybenzaldehyde 
• 21663-61-6 2,5-dichlorobenzonitrile 
• 124-41-4 sodium methylate 
• 623-12-1 4-chloromethoxybenzene 
• 4885-02-3 Dichloromethyl methyl ether 
• 6609-56-9 2-methoxy-benzonitrile 
• 13589-72-5 5-chloro-2-hydroxybenzonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 68216-06-8 ethyl 5-chloro-2-methoxybenzoate 
• 3438-16-2 5-chloro-2-methoxybenzoic acid 
• 55877-78-6 5-chloro-2-methoxy-3-nitrobenzonitrile 
• 1333152-89-8 C₉H₈ClN₃O 
• 1333151-57-7 (Z)-isopropyl 3-(3-(3-chloro-5-methoxyphenyl)-1H-1,2,4-triazol-1-yl)acrylate 
• 73220-32-3 C₁₁H₁₂ClNO₂ 
• 1354928-52-1 C₁₇H₁₁ClO₄ 
• 1354928-58-7 C₁₇H₁₁ClO₄ 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 73220-38-9 3-bromo-6-chloro-4H-1-benzopyran-4-one 
• 6342-64-9 2-methoxy-5-chloroacetophenone 
• 349088-89-7 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide 
• 29568-33-0 2-methoxy-5-chlorobenzoyl chloride 
• 1413929-89-1 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide 

Relevant academic research and scientific papers

Room temperature C(sp2)-H oxidative chlorination: Via photoredox catalysis

Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp2)-H bonds over C(sp3)-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.

FLT3 RECEPTOR ANTAGONISTS

The invention pertains to novel FLT3receptor antagonists of general formula (1). The compounds are useful for the treatment or the prevention of pain disorders, cancer and autoimmune diseases.

Facile one-pot transformation of arenes into aromatic nitriles under metal-cyanide-free conditions

Electron-rich arenes bearing methyl or methoxy groups on the aromatic ring were treated with dichloromethyl methyl ether and ZnBr2, and then with molecular iodine and aq. ammonia to give the corresponding aromatic nitriles in good yields. Using this method, febuxostat was efficiently prepared from 4-bromophenol in four steps. The method can be used for the preparation of aromatic nitriles from arenes in one pot under metal-cyanide-free conditions. Various electron-rich arenes could be effectively converted into the corresponding aromatic nitriles in good yields, by treatment with ZnBr2 and dichloromethyl methyl ether, followed by reaction with molecular iodine and aq. ammonia.

NOVEL AMIDE COMPOUNDS

A compound of the formula (I):R1-A-X-NHCO-Y-R2 ???whereinR1 is heterocyclic group which may have suitable substituents, or phenyl which may have suitable substituents,R2 is condensed phenyl which may have suitable substituents, phenyl which may have suitable substituents, or thienyl which may have suitable substituents,A is a group of the formula:-(CH2)t-(O)m- or in which R3 and R4 are each hydrogen or linked together to form imino,R5 is hydrogen or lower alkyl,t is 0, 1 or 2,p, m and n are each 0 or 1,X is phenylene which may have suitable substituents, or bivalent heterocyclic group containing nitrogen which may have suitable substituents,Y is bond, lower alkylene, or lower alkenylene, and a salt thereof.

2-Phenyl-4-(aminomethyl)imidazoles as Potential Antipsychotic Agents. Synthesis and Dopamine D2 Receptor Binding

A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D2 selective benzamide antipsychotics.The title compounds were synthesized and tested for blockade of YM-09151 binding in cloned African green monkey dopamine D2 receptor preparations.The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)pyrroles.