Benzenesulfonamide, 4-(3-ethyl-5-phenyl-4-isoxazolyl)-

Base Information

• Chemical Name: Benzenesulfonamide, 4-(3-ethyl-5-phenyl-4-isoxazolyl)-
• CAS No.: 181695-85-2
• Molecular Formula: C17H16N2O3S
• Molecular Weight: 328.392
• Mol file: 181695-85-2.mol

Synonyms:

Chemical Property of Benzenesulfonamide, 4-(3-ethyl-5-phenyl-4-isoxazolyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenesulfonamide, 4-(3-ethyl-5-phenyl-4-isoxazolyl)-

There total 12 articles about Benzenesulfonamide, 4-(3-ethyl-5-phenyl-4-isoxazolyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole (219679-74-0) → 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide (181695-85-2)

Guidance literature:

With ammonium hydroxide; In chlorosulfonic acid; water;

Reference yield:

C17H14ClNO3S → 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide (181695-85-2)

Guidance literature:

With ammonia; In water; for 1h;

Reference yield:

benzyl ethyl ketone (1007-32-5) → 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide (181695-85-2)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen bromide / acetic acid / 20 h / 0 - 20 °C

2: potassium hydroxide; hydroxylamine hydrochloride / ethanol; water / 3.5 h / 75 °C / Heating / reflux

3: iodine; sodium hydrogencarbonate; potassium iodide / tetrahydrofuran; water / 5 h / Heating / reflux

4: chlorosulfonic acid / 4 h / 0 °C

5: ammonia / water / 1 h

With chlorosulfonic acid; potassium hydroxide; hydroxylamine hydrochloride; ammonia; hydrogen bromide; iodine; sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; ethanol; water; acetic acid;

upstream raw materials:

3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole

benzyl ethyl ketone

4,5-diphenyl-3-ethylisoxazole

1,2-diphenylpent-1-en-3-one

Refernces

• 1、 -. "METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA". . . Retrieved 2008/06/13.
• 2、 -. "Substituted isoxazoles for the treatment of inflammation". Page 37. . Retrieved 2010/11/30.