4-(ChloroMethyl)quinoline hydrochloride

Base Information

• Chemical Name: 4-(ChloroMethyl)quinoline hydrochloride
• CAS No.: 1822-57-7
• Molecular Formula: C10H8ClN.ClH
• Molecular Weight: 214.09100
• Hs Code.: 2933499090
• Mol file: 1822-57-7.mol

Synonyms:4-chloromethylquinoline hydrochloride;4-CHLOROMETHYLQUINOLINE HCL;WT696;

Chemical Property of 4-(ChloroMethyl)quinoline hydrochloride

Chemical Property:

• PSA: 12.89000
• LogP: 3.77560

Purity/Quality:

97% ^*data from raw suppliers

4-(chloromethyl)quinolinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(ChloroMethyl)quinoline hydrochloride

There total 4 articles about 4-(ChloroMethyl)quinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

diethyl ether (60-29-7,927820-24-4) + 4-(hydroxymethyl)quinoline hydrobromide (142910-39-2) → 4-(chloromethyl)-quinoline hydrochloride (1822-57-7)

Guidance literature:

With thionyl chloride;

Reference yield: 65.0%

4-quinolylmethanol (6281-32-9) → 4-(chloromethyl)-quinoline hydrochloride (1822-57-7)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

quinoline-4-carboxaldehyde (4363-93-3) → 4-(chloromethyl)-quinoline hydrochloride (1822-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; sodium tetrahydroborate / 0 - 20 °C

2: thionyl chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; ethanol; In dichloromethane;

upstream raw materials:

4-quinolylmethanol

diethyl ether

4-(hydroxymethyl)quinoline hydrobromide

quinoline-4-carboxaldehyde

Downstream raw materials:

4-(4-quinolinylmethoxy)benzaldehyde

1-{[4(quinolin-4-ylmethoxy)phenyl]sulphanyl}acetone

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