Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester

Base Information

• Chemical Name: Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester
• CAS No.: 18276-81-8
• Molecular Formula: C13H19O4P
• Molecular Weight: 270.265
• Mol file: 18276-81-8.mol

Synonyms:

Chemical Property of Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester

There total 36 articles about Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

P-(2-(4-methylphenyl)ethynyl)-diethyl phosphonate → diethyl (2-oxo-2-(p-tolyl)ethyl)phosphonate (18276-81-8)

Guidance literature:

With methanol; water; silver nitrate; at 120 ℃; for 24h; Sealed tube;

DOI:10.1016/j.tet.2014.12.001

Reference yield: 90.0%

phosphonic acid diethyl ester (762-04-9) + 4-n-methylphenylacetylene (766-97-2) → diethyl (2-oxo-2-(p-tolyl)ethyl)phosphonate (18276-81-8)

Guidance literature:

With dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate; silver nitrate; In dichloromethane; water; at 20 ℃; for 3h;

DOI:10.1039/c4cc10312b

Reference yield: 90.0%

triethyl phosphite (122-52-1) → diethyl (2-oxo-2-(p-tolyl)ethyl)phosphonate (18276-81-8)

Guidance literature:

With hydrazinecarboxylic acid methyl ester; In toluene; for 2h; Dean-Stark; Reflux;

DOI:10.1021/jo401185u

upstream raw materials:

Diethyl methylphosphonate

4-methyl-benzoyl chloride

1-p-methylphenyl-1-trimethylsiloxyethene

triethyl phosphite

Downstream raw materials:

C₁₅H₂₂N₃O₄P

C₁₆H₂₄NO₃P

C₁₆H₂₄NO₃P

C₁₆H₂₄NO₃P

Refernces

• 1、 Maciás-Benítez, Pablo,Sierra-Padilla, Alfonso,Tenorio, Manuel J.,Moreno-Dorado, F. Javier,Guerra, Francisco M.. "Copper-Catalyzed Microwave-Expedited Oxyphosphorylation of Alkynes with Diethyl Phosphite and t-Butyl Hydroperoxide Synthesis of Densely Functionalized Phosphonylated Indenones". . p. 16409 - 16424. Retrieved 2021/11/16.
• 2、 -. "Bivalent copper complex containing diphosphine ortho-position carborane ligand, preparation method and application thereof". Paragraph 0029; 0033-0036. . Retrieved 2020/09/16.