poly-N(6)-methyladenylic acid

Base Information

• Chemical Name: poly-N(6)-methyladenylic acid
• CAS No.: 49717-66-0
• Molecular Formula: C11H16N5O7P
• Molecular Weight: 361.251
• Mol file: 49717-66-0.mol

Synonyms:poly-N(6)-methyladenylic acid

Chemical Property of poly-N(6)-methyladenylic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of poly-N(6)-methyladenylic acid

There total 9 articles about poly-N(6)-methyladenylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

triethyl phosphate (78-40-0) + N6-methyladenosine (1867-73-8) → N6-methyl AMP (4229-50-9,49717-66-0) + C11H17N5O10P2 (1359697-50-9)

Guidance literature:

With water; trichlorophosphate; at 0 ℃;

DOI:10.1021/jm201127y

Reference yield:

N6-methyladenosine (1867-73-8) → N6-methyl AMP (4229-50-9,49717-66-0)

Guidance literature:

With triethyl phosphate; water; trichlorophosphate; at 0 ℃; for 2h;

DOI:10.1021/jm900728u

Reference yield:

C11H14Cl2N5O5P → N6-methyl AMP (4229-50-9,49717-66-0) + N6-Methyl-ATP (3130-39-0)

Guidance literature:

With tributyl-amine; bis(tri-n-butylammonium) pyrophosphate; In N,N-dimethyl-formamide; at -15 ℃; for 2h;

DOI:10.1080/15257771003709569

upstream raw materials:

N⁶-methyladenosine

2',3',5'-O-triacetyl-6-chloroinosine

6-N-methyladenosine 5'-acetate

triethyl phosphate

Refernces

• 1、 Gillerman, Irina,Fischer, Bilha. "An improved one-pot synthesis of nucleoside 5'-triphosphate analogues". experimental part. p. 245 - 256. Retrieved 2011/08/06.