Cyclopropanecarboxylic acid, 2-(4-methylphenyl)-, ethyl ester, (1R,2R)-rel-

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 2-(4-methylphenyl)-, ethyl ester, (1R,2R)-rel-
CAS No.:18456-66-1
Molecular Formula:C₁₃H₁₆O₂
Molecular Weight:204.269
Hs Code.:
Mol file:18456-66-1.mol

Synonyms:ethyl trans-3-(4-methylphenyl)-cyclopropanecarboxylate;trans-ethyl 2-p-tolylcyclopropanecarboxylate;(1RS,2RS)-ethyl 2-(p-tolyl)cyclopropanecarboxylate;(1R*,2R*)-ethyl 2-(p-tolyl)cyclopropanecarboxylate;ethyl 2-(4-methylphenyl)cyclopropane-1-carboxylate;ethyl trans-2-(4-methylphenyl)cyclopropane-1-carboxylate;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopropanecarboxylic acid, 2-(4-methylphenyl)-, ethyl ester, (1R,2R)-rel-

Chemical Property:

PSA：26.30000
LogP:2.66160

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-(4-methylphenyl)-, ethyl ester, (1R,2R)-rel-

There total 20 articles about Cyclopropanecarboxylic acid, 2-(4-methylphenyl)-, ethyl ester, (1R,2R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 97585-04-1,20511-20-0,24393-49-5
ethyl (E)-3-(4-methylphenyl)acrylate

: 18456-66-1,70461-59-5,97023-67-1
(1R*,2R*)-ethyl 2-(p-tolyl)cyclopropanecarboxylate

Guidance literature:: With palladium diacetate; In diethyl ether; for 1h; Ambient temperature;
DOI:10.1248/cpb.43.2075

Reference yield: 80.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 623-73-4
diazoacetic acid ethyl ester

: 104-87-0
4-methyl-benzaldehyde

: 18456-66-1,70461-59-5,97023-67-1
(1R*,2R*)-ethyl 2-(p-tolyl)cyclopropanecarboxylate

Guidance literature:: diazoacetic acid ethyl ester; 4-methyl-benzaldehyde; With copper(l) iodide; triphenylphosphine; In dichloromethane; at 40 ℃; Inert atmosphere;

diazomethane; With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In dichloromethane; at -78 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/b810708d

Reference yield: 78.0%

: 623-73-4
diazoacetic acid ethyl ester

: 622-97-9,24936-41-2
1-ethenyl-4-methylbenzene

: 18456-66-1,70461-59-5,97023-67-1
ethyl cis-2-(4-methylphenyl)cyclopropane-1-carboxylate

: 18456-66-1,70461-59-5,97023-67-1
(1R*,2R*)-ethyl 2-(p-tolyl)cyclopropanecarboxylate

Guidance literature:: With C₇₇H₅₅Cl₄FeN₈O₅; In toluene; at 25 ℃; for 0.0833333h; Temperature; diastereoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201602289