N-(3-chlorophenyl)-2-oxo-2H-chromene-3-carboxamide

Base Information

Chemical Name:N-(3-chlorophenyl)-2-oxo-2H-chromene-3-carboxamide
CAS No.:1847-01-4
Molecular Formula:C16H10ClNO3
Molecular Weight:299.70900
Hs Code.:
DSSTox Substance ID:DTXSID901210065
Nikkaji Number:J497.229E
Pharos Ligand ID:4R7QV3WN7K1M
ChEMBL ID:CHEMBL4870855
Mol file:1847-01-4.mol

Synonyms:1847-01-4;CHEMBL4870855;N-(3-chlorophenyl)-2-oxo-2H-chromene-3-carboxamide;N-(3-Chlorophenyl)-2-oxo-2H-1-benzopyran-3-carboxamide;2H-1-Benzopyran-3-carboxamide, N-(3-chlorophenyl)-2-oxo-;Oprea1_452806;Oprea1_571078;2-Oxo-2H-chromene-3-carboxylic acid (3-chloro-phenyl)-amide;DTXSID901210065;BDBM50566804;CCG-15836;STK709457;AKOS000533732;SR-01000410415;SR-01000410415-1;Z28141263;2h-1-benzopyran-3-carboxamide,n-(3-chlorophenyl)-2-oxo-

Suppliers and Price of N-(3-chlorophenyl)-2-oxo-2H-chromene-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of N-(3-chlorophenyl)-2-oxo-2H-chromene-3-carboxamide

Chemical Property:

Melting Point:90 °C (petroleum ether)
PSA：59.31000
LogP:3.77170
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:299.0349209
Heavy Atom Count:21
Complexity:462

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=C(C(=O)O2)C(=O)NC3=CC(=CC=C3)Cl

Technology Process of N-(3-chlorophenyl)-2-oxo-2H-chromene-3-carboxamide

There total 4 articles about N-(3-chlorophenyl)-2-oxo-2H-chromene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886124-83-0
C₁₃H₈N₂O₃

: 108-42-9
3-chloro-aniline

: 1847-01-4
2-oxo-2H-chromene-3-carboxylic acid (3-chloro-phenyl)-amide

Guidance literature:: In acetonitrile; at 20 ℃; for 16h;
DOI:10.2174/1573406413666170623083116

Reference yield:

: 1846-76-0
ethyl coumarin-3-carboxylate

: 1847-01-4
2-oxo-2H-chromene-3-carboxylic acid (3-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / conc. HCl / ethanol / 8 h / Heating

2: 60 percent / DCC / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

Reference yield:

: 90-02-8
salicylaldehyde

: 1847-01-4
2-oxo-2H-chromene-3-carboxylic acid (3-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water / 20 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1.5 h / 20 °C

2.2: 0 °C

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; water;
DOI:10.1016/j.fitote.2018.03.013