8-Quinolinol, 7-amino-5-chloro-

Base Information

• Chemical Name: 8-Quinolinol, 7-amino-5-chloro-
• CAS No.: 18471-93-7
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.62
• Mol file: 18471-93-7.mol

Synonyms:7-amino-5-chloro-8-hydroxyquinoline;5-Chlor-7-amino-8-hydroxy-chinolin;7-amino-5-chloro-quinolin-8-ol;7-amino-5-chloroquinolin-8-ol;5-chloro-7-aminoquinolin-8-ol;

Chemical Property of 8-Quinolinol, 7-amino-5-chloro-

Chemical Property:

• Melting Point: 162-164 °C(Solv: ethanol (64-17-5))
• Boiling Point: 400.3±45.0 °C(Predicted)
• PKA: 3.56±0.30(Predicted)
• PSA: 59.14000
• Density: 1.503±0.06 g/cm3(Predicted)
• LogP: 2.75720

Purity/Quality:

99% ^*data from raw suppliers

7-Amino-5-chloroquinolin-8-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Quinolinol, 7-amino-5-chloro-

There total 3 articles about 8-Quinolinol, 7-amino-5-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-chloro-7-nitro-8-hydroxy-quinoline (18472-03-2) → 7-amino-5-chloro-8-hydroxyquinoline (18471-93-7)

Guidance literature:

With sodium dithionite; water; In methanol; at 20 ℃; for 16h;

Reference yield:

5-Chloro-8-hydroxyquinoline (130-16-5) → 7-amino-5-chloro-8-hydroxyquinoline (18471-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / 90percent HNO₃, H₂SO₄ / 1 h / 0 °C

2: 70 percent / sodium dithionite / methanol; H₂O

With sodium dithionite; sulfuric acid; nitric acid; In methanol; water;

DOI:10.1021/jm00147a023

Reference yield:

→ 7-amino-5-chloro-8-hydroxyquinoline (18471-93-7)

Guidance literature:

5-Chlor-7-nitro-8-hydroxy-chinolin, NaHSO3, wss. Py., Raumtemp.;

DOI:10.1021/jo01075a621

upstream raw materials:

5-chloro-7-nitro-8-hydroxy-quinoline

5-Chloro-8-hydroxyquinoline

Downstream raw materials:

methyl 5-chloroxazolo <4,5-h> quinoline-2-carboxylate

5-Chloro-2-phenyl-oxazolo[4,5-h]quinoline

5-Chloro-3-[(E)-(3-phenyl-acryloyl)]-3H-oxazolo[4,5-h]quinolin-2-one

5-Chloro-2-oxo-oxazolo[4,5-h]quinoline-3-carboxylic acid 2-methoxy-phenyl ester