tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate

Base Information

Chemical Name:tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate
CAS No.:940298-42-0
Molecular Formula:C₂₇H₂₅ClN₄O₄
Molecular Weight:504.973
Hs Code.:

Synonyms:tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate

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Chemical Property of tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate

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Technology Process of tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate

There total 3 articles about tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39930-11-5
1-phenyl-1-(pyridin-2-yl)methanamine

: 24424-99-5
di-tert-butyl dicarbonate

: 18471-93-7
7-amino-5-chloro-8-hydroxyquinoline

: 7693-46-1
4-Nitrophenyl chloroformate

: 940298-42-0
tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate

Guidance literature:: di-tert-butyl dicarbonate; 7-amino-5-chloro-8-hydroxyquinoline; With pyridine; In tetrahydrofuran; at 20 ℃; for 18h;

4-Nitrophenyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h;

1-phenyl-1-(pyridin-2-yl)methanamine; In tetrahydrofuran; at 20 ℃; for 120h;

Reference yield:

: 130-16-5
5-Chloro-8-hydroxyquinoline

: 940298-42-0
tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; nitric acid / water / 2 h / 0 °C

2.1: sodium dithionite; water / methanol / 16 h / 20 °C

3.1: pyridine / tetrahydrofuran / 18 h / 20 °C

3.2: 1 h / 20 °C

3.3: 120 h / 20 °C

With pyridine; sodium dithionite; sulfuric acid; water; nitric acid; In tetrahydrofuran; methanol; water;

Reference yield:

: 18472-03-2
5-chloro-7-nitro-8-hydroxy-quinoline

: 940298-42-0
tert-butyl 5-chloro-7-[3-(phenylpyridin-2-ylmethyl)ureido]quinolin-8-yloxycarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium dithionite; water / methanol / 16 h / 20 °C

2.1: pyridine / tetrahydrofuran / 18 h / 20 °C

2.2: 1 h / 20 °C

2.3: 120 h / 20 °C

With pyridine; sodium dithionite; water; In tetrahydrofuran; methanol;