Carbamic acid, [(1S)-1-[[(2S)-2-[(butylamino)carbonyl]-2,3-dihydro-1H-indol-1-yl]carbon yl]propyl]-, phenylmethyl ester

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Chemical Name:Carbamic acid, [(1S)-1-[[(2S)-2-[(butylamino)carbonyl]-2,3-dihydro-1H-indol-1-yl]carbon yl]propyl]-, phenylmethyl ester
CAS No.:185213-02-9
Molecular Formula:C25H31N3O4
Molecular Weight:437.539
Hs Code.:
Mol file:185213-02-9.mol

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-1-[[(2S)-2-[(butylamino)carbonyl]-2,3-dihydro-1H-indol-1-yl]carbon yl]propyl]-, phenylmethyl ester

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Technology Process of Carbamic acid, [(1S)-1-[[(2S)-2-[(butylamino)carbonyl]-2,3-dihydro-1H-indol-1-yl]carbon yl]propyl]-, phenylmethyl ester

There total 4 articles about Carbamic acid, [(1S)-1-[[(2S)-2-[(butylamino)carbonyl]-2,3-dihydro-1H-indol-1-yl]carbon yl]propyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 42918-86-5,1145-79-5,2900-20-1,20395-87-3
(S)-2-(((benzyloxy)carbonyl)amino)butanoic acid

: 185213-01-8
(2S)-indolinecarboxylic acid n-butylamide

: 185213-02-9
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid n-butylamide

Guidance literature:: (S)-2-(((benzyloxy)carbonyl)amino)butanoic acid; With N-ethylmorpholine;; isobutyl chloroformate; In tetrahydrofuran; for 0.5h;

(2S)-indolinecarboxylic acid n-butylamide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm0500830

Reference yield:

: 185213-00-7
N-benzyloxycarbonyl-(2S)-indolinecarboxylic acid n-butylamide

: 185213-02-9
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid n-butylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / H₂ / Pd/C / methanol / 3 h / 25 °C / 1551.44 Torr

2.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

2.2: 65 percent / tetrahydrofuran / 20 °C

With N-ethylmorpholine;; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0500830

Reference yield:

: 104261-79-2
(S)-1-(benzyloxycarbonyl)indoline-2-carboxylic acid

: 185213-02-9
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid n-butylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

1.2: 80 percent / tetrahydrofuran / 20 °C

2.1: 80 percent / H₂ / Pd/C / methanol / 3 h / 25 °C / 1551.44 Torr

3.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

3.2: 65 percent / tetrahydrofuran / 20 °C

With N-ethylmorpholine;; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0500830