3-Chloro-6-morpholinopyridazine

Base Information

• Chemical Name: 3-Chloro-6-morpholinopyridazine
• CAS No.: 17259-32-4
• Molecular Formula: C8H10ClN3O
• Molecular Weight: 199.64
• Hs Code.: 29335990
• Mol file: 17259-32-4.mol

Synonyms:3-chloro-6-morpholin-4-yl-pyridazine;4-(6-Chloropyridazin-3-yl)morpholine;

Chemical Property of 3-Chloro-6-morpholinopyridazine

Chemical Property:

• Vapor Pressure: 3.12E-07mmHg at 25°C
• Refractive Index: 1.563
• Boiling Point: 419.1 °C at 760 mmHg
• Flash Point: 207.3 °C
• PSA: 38.25000
• Density: 1.32 g/cm³
• LogP: 1.03160

Purity/Quality:

99% ^*data from raw suppliers

4-(6-Chloropyridazin-3-yl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-6-morpholinopyridazine

There total 2 articles about 3-Chloro-6-morpholinopyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 3,6-dichlorpyridazine (141-30-0) → 4-(6-chloropyridazin-3-yl)morpholine (17259-32-4)

Guidance literature:

With triethylamine; In ethanol; for 4.5h; Solvent; Reagent/catalyst; Temperature; Reflux;

DOI:10.1016/j.tet.2015.05.056

Reference yield:

→ 4-(6-chloropyridazin-3-yl)morpholine (17259-32-4)

Guidance literature:

aus /BRN= 111151/, Morpholin;

Reference yield: 70.0%

ethyl 3-bromobenzoate (24398-88-7) + 4-(6-chloropyridazin-3-yl)morpholine (17259-32-4) → ethyl 3-(6-morpholinopyridazin-3-yl)benzoate (1417454-99-9)

Guidance literature:

With bis(bipyridine)nickel(II) bromide; tetrabutylammomium bromide; In ethylene dibromide; N,N-dimethyl-formamide; at 20 ℃; for 3.5h; Electrochemical reaction; Inert atmosphere;

DOI:10.1021/jo3022428

upstream raw materials:

morpholine

3,6-dichlorpyridazine

Downstream raw materials:

4-(pyridazin-3-yl)morpholine

3-Hydroxy-6-morpholino-pyridazin

6-morpholinopyridazin-3(2H)-one

methyl 4-[(6-morpholin-4-yl-pyridazin-3-ylamino)-methyl]-benzoate

Refernces

• 1、 Sengmany, Stéphane,Lebre, Julie,Le Gall, Ewan,Léonel, Eric. "Selective mono-amination of dichlorodiazines". . p. 4859 - 4867. Retrieved 2015/08/03.
• 2、 Sengmany, Stephane,Vitu-Thiebaud, Arnaud,Le Gall, Erwan,Condon, Sylvie,Leonel, Eric,Thobie-Gautier, Christine,Pipelier, Muriel,Lebreton, Jacques,Dubreuil, Didier. "An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines". . p. 370 - 379. Retrieved 2013/03/13.