3-(3-CHLORO-PHENYL)-PROPYLAMINE

Base Information

• Chemical Name: 3-(3-CHLORO-PHENYL)-PROPYLAMINE
• CAS No.: 18655-49-7
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Hs Code.: 2921499090
• Mol file: 18655-49-7.mol

Synonyms:3-(3-CHLORO-PHENYL)-PROPYLAMINE;3-(3-CHLOROPHENYL)PROPAN-1-AMINE;OTAVA-BB 1038718;3-Chloro-benzenepropanaMine

Chemical Property of 3-(3-CHLORO-PHENYL)-PROPYLAMINE

Chemical Property:

• Boiling Point: 252.3±23.0 °C(Predicted)
• PKA: 10.16±0.10(Predicted)
• PSA: 26.02000
• Density: 1.098±0.06 g/cm3(Predicted)
• LogP: 2.93160

Purity/Quality:

98%min ^*data from raw suppliers

3-(3-chlorophenyl)propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-CHLORO-PHENYL)-PROPYLAMINE

There total 12 articles about 3-(3-CHLORO-PHENYL)-PROPYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C9H10ClN3 → 3-(3-Chloro-phenyl)-propylamine (18655-49-7)

Guidance literature:

C₉H₁₀ClN₃; With triethyl phosphite; In benzene; for 18h; Reflux;

With hydrogenchloride; In methanol; benzene; for 3h; Reflux;

DOI:10.1021/jm501719e

Reference yield: 44.0%

3‐(3‐chlorophenyl)propanenitrile (21640-47-1) → 3-(3-Chloro-phenyl)-propylamine (18655-49-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm9603936

Reference yield:

3-(3-chloro-phenyl)-acrylamide (24654-56-6) → 3-(3-Chloro-phenyl)-propylamine (18655-49-7)

Guidance literature:

3-(3-chloro-phenyl)-acrylamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 47h;

With water; In tetrahydrofuran;

upstream raw materials:

3‐(3‐chlorophenyl)propanenitrile

2-(3-chlorophenyl)ethanol

2-(3-chlorophenyl)ethyl bromide

3-(3-chloro-phenyl)-acrylamide

Refernces

• 1、 Mukherjee, Paramita,Li, Huiying,Sevrioukova, Irina,Chreifi, Georges,Martásek, Pavel,Roman, Linda J.,Poulos, Thomas L.,Silverman, Richard B.. "Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase". . p. 1067 - 1088. Retrieved 2015/03/04.
• 2、 -. "Prostaglandin agonists and their use to treat bone disorders". . . Retrieved 2008/06/13.