2-(benzyloxy)-5-broMobenzenaMine

Base Information

• Chemical Name: 2-(benzyloxy)-5-broMobenzenaMine
• CAS No.: 186797-58-0
• Molecular Formula: C13H12BrNO
• Molecular Weight: 278.148
• Hs Code.: 2922199090
• Mol file: 186797-58-0.mol

Synonyms:QC-3500;2-benzyloxy-5-bromo-aniline;2-benzyloxy-5-bromophenylamine;4-Brom-2-amino-phenol-benzylaether;2-benzyloxy-5-bromobenzamine;2-Benzyloxy-5-brom-anilin;

Chemical Property of 2-(benzyloxy)-5-broMobenzenaMine

Chemical Property:

• PSA: 35.25000
• LogP: 4.19150

Purity/Quality:

98%min ^*data from raw suppliers

2-(Benzyloxy)-5-bromoaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzyloxy)-5-broMobenzenaMine

There total 5 articles about 2-(benzyloxy)-5-broMobenzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(benzyloxy)-4-bromo-2-nitrobenzene (383868-64-2) → 2-(benzyloxy)-5-bromoaniline (186797-58-0)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate;

DOI:10.1016/j.tet.2014.10.061

Reference yield:

4-bromo-2-nitrophenol (7693-52-9) → 2-(benzyloxy)-5-bromoaniline (186797-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: tin(II) chloride dihdyrate / ethyl acetate

With tin(II) chloride dihdyrate; potassium carbonate; In ethyl acetate; acetone;

DOI:10.1016/j.tet.2014.10.061

Reference yield:

benzyl bromide (100-39-0) → 2-(benzyloxy)-5-bromoaniline (186797-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3.67 h / 50 - 72 °C

2: acetic acid / iron / ethanol / 2 h / 100 °C

With potassium carbonate; acetic acid; iron; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

1-(benzyloxy)-4-bromo-2-nitrobenzene

4-bromo-phenol

4-bromo-2-nitrophenol

benzyl bromide

Downstream raw materials:

1-Benzyloxy-4-bromo-2-isothiocyanato-benzene

(2-benzyloxy-5-bromophenylamino)-acetic acid ethyl ester

5-(2-benzyloxy-5-bromophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one

2-[4-hydroxy-3-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-pyrrole-1-carboxylic acid tert-butyl ester

Refernces

• 1、 Liu, Xuge,Yang, Zhilin,Li, Ya-Min,Yang, Fan,Feng, Liang,Wang, Nengzhong,Ma, Debiao,Chang, Kwen-Jen,Shen, Yuehai. "A practical nickel-catalyzed reductive alkylation of amidophenyl bromides". . p. 9522 - 9529. Retrieved 2015/03/04.
• 2、 -. "HETEROCYCLYL COMPOUNDS". Page/Page column 32. . Retrieved 2010/02/11.