1,5-Hexadien-3-ol, 2-methyl-1-(2-methyl-4-thiazolyl)-, (1E,3S)-

Base Information

Chemical Name:1,5-Hexadien-3-ol, 2-methyl-1-(2-methyl-4-thiazolyl)-, (1E,3S)-
CAS No.:187283-46-1
Molecular Formula:C11H15NOS
Molecular Weight:209.312
Hs Code.:

Synonyms:

Suppliers and Price of 1,5-Hexadien-3-ol, 2-methyl-1-(2-methyl-4-thiazolyl)-, (1E,3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 1,5-Hexadien-3-ol, 2-methyl-1-(2-methyl-4-thiazolyl)-, (1E,3S)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,5-Hexadien-3-ol, 2-methyl-1-(2-methyl-4-thiazolyl)-, (1E,3S)-

There total 1 articles about 1,5-Hexadien-3-ol, 2-methyl-1-(2-methyl-4-thiazolyl)-, (1E,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 187283-46-1
(S,E)-2-methyl-1-(2-methylthiazol-4-yl)hexa-1,5-dien-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / DIBAL-H

2: 89 percent

3: 1) (S)-BINOL-Ti(OiPr)4

With (S)-BINOL-Ti(OiPr)4; diisobutylaluminium hydride;
DOI:10.1016/S0040-4039(97)00285-2

Reference yield:

: 187283-46-1
(S,E)-2-methyl-1-(2-methylthiazol-4-yl)hexa-1,5-dien-3-ol

: 152044-54-7
epothilone B

Guidance literature:: Multi-step reaction with 14 steps

1.1: OsO₄

1.2: 80 percent / NaIO₄

2.1: 93 percent / NiCl₂; CrCl₂ / dimethylformamide / 0.67 h / 20 °C

3.1: 87 percent / SOCl₂ / diethyl ether; pentane / 6.5 h / -78 - 0 °C

4.1: 88 percent / LiEt₃BH / tetrahydrofuran / 2 h / -78 - 20 °C

5.1: 80 percent / PCC

6.1: LDA

7.1: 88 percent / CSA / methanol

8.1: PCC

8.2: 90 percent / NaClO₂

9.1: 73 percent / TBAF

10.1: 77 percent / TCBCl; DIEA; DMAP

11.1: 59 percent / HF*pyr

12.1: 65 percent / mCPBA

With chromium dichloride; dmap; osmium(VIII) oxide; thionyl chloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; lithium triethylborohydride; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; nickel dichloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ol010094x

Reference yield:

: 187283-46-1
(S,E)-2-methyl-1-(2-methylthiazol-4-yl)hexa-1,5-dien-3-ol

: 189453-10-9
epothilone D

Guidance literature:: Multi-step reaction with 3 steps

1: EDC; DMAP / CH₂Cl₂

2: 59 percent / second-generation Grubbs catalyst / CH₂Cl₂ / 6 h / Heating

3: TFA / CH₂Cl₂ / 0 - 20 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;
DOI:10.1016/j.tetlet.2003.12.123