[6-(4-Methylphenyl)pyridazin-3-yl]hydrazine

Base Information

• Chemical Name: [6-(4-Methylphenyl)pyridazin-3-yl]hydrazine
• CAS No.: 18772-77-5
• Molecular Formula: C11H12N4
• Molecular Weight: 200.24
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00423513
• Mol file: 18772-77-5.mol

Synonyms:18772-77-5;[6-(4-methylphenyl)pyridazin-3-yl]hydrazine;3-Hydrazino-6-(4-methylphenyl)pyridazine;3-Hydrazinyl-6-(p-tolyl)pyridazine;CHEMBRDG-BB 4000237;MFCD05863651;SCHEMBL10816679;DTXSID00423513;STL573005;AKOS004093136;AKOS030241152;3-HYDRAZINYL-6-(4-METHYLPHENYL)PYRIDAZINE

Chemical Property of [6-(4-Methylphenyl)pyridazin-3-yl]hydrazine

Chemical Property:

• Vapor Pressure: 1.36E-08mmHg at 25°C
• Refractive Index: 1.657
• Boiling Point: 458.5°C at 760 mmHg
• PKA: 5.94±0.20(Predicted)
• Flash Point: 231.1°C
• PSA: 63.83000
• Density: 1.22g/cm³
• LogP: 2.51090
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 200.106196400
• Heavy Atom Count: 15
• Complexity: 189

Purity/Quality:

99% ^*data from raw suppliers

3-hydrazino-6-(4-methylphenyl)pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NN=C(C=C2)NN

Technology Process of [6-(4-Methylphenyl)pyridazin-3-yl]hydrazine

There total 5 articles about [6-(4-Methylphenyl)pyridazin-3-yl]hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-(4-methylphenyl)-6-chloropyridazine (2165-06-2) → 3-(4-methylphenyl)-6-hydrazinopyridazine (18772-77-5)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; for 6h; Reflux;

DOI:10.1002/jhet.357

Reference yield:

3-(4-methylbenzoyl)propionic acid (4619-20-9) → 3-(4-methylphenyl)-6-hydrazinopyridazine (18772-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate; hydrazine hydrate / methanol / 6 h / Reflux

2: trichlorophosphate / 6 h / Heating

3: hydrazine hydrate / ethanol / 16 h / Reflux

With sodium acetate; hydrazine hydrate; trichlorophosphate; In methanol; ethanol;

Reference yield:

6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone (1079-72-7) → 3-(4-methylphenyl)-6-hydrazinopyridazine (18772-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 6 h / Heating

2: hydrazine hydrate / ethanol / 16 h / Reflux

With hydrazine hydrate; trichlorophosphate; In ethanol;

upstream raw materials:

3-(4-methylphenyl)-6-chloropyridazine

6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone

3-(4-methylbenzoyl)propionic acid

toluene

Downstream raw materials:

5-amino-3-methylthio-1[6-(p-tolyl)pyridazin-3-yl]-pyrazole-4-carbonitrile

5-amino-[6-(p-tolyl)pyridazin-3-yl]-pyrazole-3,4-dicarbonitrile

6-(4'''-bromophenyl)-2-[3'-(4''-tolyl)pyridazin-6'-yl]-2,3,4,5-tetrahydropyridazin-3-one

6-(4'''-biphenyl)-2-[3'-(4''-tolyl)pyridazin-6'-yl]-2,3,4,5-tetrahydropyridazin-3-one