1079-72-7

Basic information

• Product Name: 6-(p-tolyl)-4,5-dihydro-3(2H)-pyridazinone
• Synonyms: 6-(p-tolyl)-4,5-dihydro-3(2H)-pyridazinone;2,3,4,5-Tetrahydro-6-(4-methylphenyl)-3-pyridazinone;4,5-Dihydro-6-(4-methylphenyl)-3-(2H)-pyridazinone;4,5-Dihydro-6-p-tolyl-3(2H)-pyridazinone;6-(4-Methylphenyl)-4,5-dihydro-3(2H)-pyridazinone
• CAS NO: 1079-72-7
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.22578
• EINECS: -0
• Mol File: 1079-72-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 157-158℃
• Appearance: /
• Density: 1.18
• CAS DataBase Reference: 6-(p-tolyl)-4,5-dihydro-3(2H)-pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(p-tolyl)-4,5-dihydro-3(2H)-pyridazinone(1079-72-7)
• EPA Substance Registry System: 6-(p-tolyl)-4,5-dihydro-3(2H)-pyridazinone(1079-72-7)

Safety Data

• Hazardous Substances Data: 1079-72-7(Hazardous Substances Data)

Upstream product

• 59618-44-9 4-(3-methylphenyl)-4-oxobutanoic acid 
• 108-88-3 toluene 
• 57498-54-1 methyl 4-(4-methylphenyl)-4-oxobutanoate 
• 21053-98-5 5-(4-methylphenyl)-3H-furan-2-one 
• 4619-20-9 3-(4-methylbenzoyl)propionic acid 

Downstream Products

• 4521-22-6 4-(4-methylphenyl)butyric acid 
• 76617-81-7 6-Phenyl-6-p-tolyl-tetrahydro-pyridazin-3-one 
• 121137-73-3 4-(2-methoxyphenylmethyl)-6-(4-tolyl)-pyridazine-3(2H)-one 
• 2166-32-7 6-(4-methylphenyl)-3(2H)-pyridazinone 
• 58112-75-7 6-(4-methylphenyl)-2-(piperidin-1-ylmethyl)-4,5-dihydropyridazin-3(2H)-one 
• 1229036-99-0 6-(4-methylphenyl)-2-(piperazin-1-ylmethyl)-4,5-dihydropyridazin-3(2H)-one 
• 1229037-00-6 6-(4-methylphenyl)-2-[(4-methylpiperazin-1-yl)methyl]-4,5-dihydropyridazin-3(2H)-one 
• 1229037-05-1 6-(4-methylphenyl)-2-(2,3-dihydro-1H-1,2,4-triazol-1-ylmethyl)-4,5-dihydropyridazin-3(2H)-one 
• 1427435-34-4 7-(4-methylphenyl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine 
• 1427435-35-5 7-(4-methylphenyl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-one 
• 1427435-36-6 7-(4-methylphenyl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-thione 
• 58162-49-5 2-hydroxymethyl-6-p-tolyl-4,5-dihydro-2H-pyridazin-3-one 
• 58112-63-3 4-[(4-methoxyphenyl)methylidene]-6-(4-methylphenyl)-4,5-dihydropyridazin-3(2H)-one 
• 58112-64-4 4-(4-chloro-benzylidene)-6-(4-methyl-phenyl)-4,5-dihydropyridazin-3(2H)-one 

Relevant articles and documents

Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues

Pyridazinone analogues have been known to be potential candidates for anticonvulsant agents. We have identified several pyridazinone-based anticonvulsant agents. As a continuation to our previous research, a series of hybrid pyridazinone-thiazole connected through amide linkage were designed and synthesized. Among these, compound SP-5F demonstrated significant anticonvulsant activity with median effective dose of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Molecular docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of SP-5F.

Synthesis and anti-tubercular activity of 6-(4-chloro/methyl-phenyl)-4-arylidene-4,5-dihydropyridazin-3(2H)-one derivatives against Mycobacterium tuberculosis

Two series of 6-(4-Cl-Phenyl)-4-arylidene-4,5-dihydropyridazin-3(2H)-one (3a-e) and 6-(4-CH3-Phenyl)-4-arylidene-4,5-dihydropyridazin-3(2H)-one derivatives (3f-j) were synthesized and evaluated as antitubercular agents against Mycobacterium tuberculosis H37Rv strain by using Microplate Alamar Blue Assay (MABA) method. These compounds (3a-e & 3f-j) were synthesized from 6-(4-Cl-Phenyl)-4,5-dihydropyridazin-3(2H)-one (2a) and 6-(4-CH3-Phenyl)-4,5-dihydropyridazin-3(2H)-one (2b) compounds by reacting with appropriate aldehydes respectively. All title compounds (3a-e & 3f-j) were characterized on the basis of IR, 1HNMR, mass spectral and elemental analysis data. All title compounds (3a-e & 3f-j) were used at 0.2μg/mL to 100μg/mL dose levels for antitubercular activity. Result showed that all the title compounds (3a-e & 3f-j) exhibited less antitubercular activity as compared to the reference drugs streptomycin (MIC value of 6.25μg/mL) and pyrizinamide (MIC value of 3.125μg/mL), except compound 3e, which was equally effective as streptomycin but less effective than pyrazinamide.

Design, synthesis and antihypertensive screening of novel pyridazine substituted s-triazin-2-imine/one/thione derivatives

Some new 7-substituted-phenyl-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds were screened for antihypertensive activities by non-invasive method using Tail Cuff method. All the test compounds showed significant antihypertensive activity; 7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine (4p) exhibited antihypertensive activity more than the reference standard drugs.