Butanoic acid, 2-[2-(4-chlorophenyl)hydrazinylidene]-3-oxo-, ethyl ester

Base Information

• Chemical Name: Butanoic acid, 2-[2-(4-chlorophenyl)hydrazinylidene]-3-oxo-, ethyl ester
• CAS No.: 18794-97-3
• Molecular Formula: C₁₂H₁₃ClN₂O₃
• Molecular Weight: 268.7
• Hs Code.: 2928000090
• Mol file: 18794-97-3.mol

Synonyms:4-chlorophenyl-hydrazono-ethyl-2,3-dioxobutyrate;

Chemical Property of Butanoic acid, 2-[2-(4-chlorophenyl)hydrazinylidene]-3-oxo-, ethyl ester

Chemical Property:

• PSA: 67.76000
• LogP: 2.33300

Purity/Quality:

99% ^*data from raw suppliers

ethyl2-[(4-chlorophenyl)hydrazono]-3-oxobutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 2-[2-(4-chlorophenyl)hydrazinylidene]-3-oxo-, ethyl ester

There total 4 articles about Butanoic acid, 2-[2-(4-chlorophenyl)hydrazinylidene]-3-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl acetoacetate (141-97-9) + 4-chloro-aniline (106-47-8) → ethyl 2-(4-chlorophenylhydrazono)-3-oxobutyrate (18794-97-3,73981-88-1)

Guidance literature:

4-chloro-aniline; With hydrogenchloride; sodium hydroxide; sodium nitrite; In water; at -0.16 ℃;

ethyl acetoacetate; In water; at -0.16 ℃; for 1h;

DOI:10.1016/j.ejmech.2019.01.021

Reference yield:

p-chlorobenzenediazonium chloride (2028-74-2) + ethyl acetoacetate (141-97-9) → ethyl 2-(4-chlorophenylhydrazono)-3-oxobutyrate (18794-97-3,73981-88-1)

Guidance literature:

Reference yield:

4-chloro-aniline (106-47-8) → ethyl 2-(4-chlorophenylhydrazono)-3-oxobutyrate (18794-97-3,73981-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; hydrogenchloride / 0 - 2 °C

2: sodium acetate

With hydrogenchloride; sodium acetate; sodium nitrite;

upstream raw materials:

p-chlorobenzenediazonium chloride

ethyl acetoacetate

4-chloro-aniline

Downstream raw materials:

ethyl 2-chloro[(4-chlorophenyl)hydrazono]acetate

4-[(4-Chloro-phenyl)-hydrazono]-5-methyl-2-(pyridine-4-carbonyl)-2,4-dihydro-pyrazol-3-one

2-(4,6-dimethyl-pyrimidin-2-yl)-5-methyl-2H-pyrazole-3,4-dione 4-[(4-chloro-phenyl)-hydrazone]

4-[(4-Chloro-phenyl)-hydrazono]-2-(3,5-dinitro-benzoyl)-5-methyl-2,4-dihydro-pyrazol-3-one