Technology Process of 2-Pentenoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, methyl ester,
(2Z,4S)-
There total 4 articles about 2-Pentenoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, methyl ester,
(2Z,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
Inert atmosphere;
(S)-2-(O-tert-butyldiphenylsilyloxy)propanal;
In
tetrahydrofuran; mineral oil;
at -78 ℃;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2010.08.068
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisobutylaluminium hydride / diethyl ether / 3 h / -78 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C
2.2: 9.5 h / -78 - -55 °C
With
sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; diethyl ether; mineral oil;
2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/acs.orglett.0c03308
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1H-imidazole / dichloromethane / 12 h / 0 - 23 °C
2.1: diisobutylaluminium hydride / diethyl ether / 3 h / -78 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C
3.2: 9.5 h / -78 - -55 °C
With
1H-imidazole; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; mineral oil;
3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/acs.orglett.0c03308
