N-((S)-1-phenylethyl)acrylamide

Base Information

• Chemical Name: N-((S)-1-phenylethyl)acrylamide
• CAS No.: 19035-71-3
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• DSSTox Substance ID: DTXSID20467196
• Nikkaji Number: J51.803D
• Wikidata: Q82294007
• Mol file: 19035-71-3.mol

Synonyms:N-((S)-1-phenylethyl)acrylamide;19035-71-3;N-[(1S)-1-phenylethyl]prop-2-enamide;2-Propenamide, N-[(1S)-1-phenylethyl]-;(S)-N-(1-phenylethyl)acrylamide;SCHEMBL5527681;DTXSID20467196;RBVOJZBQNQTPRA-VIFPVBQESA-N;L-N-(alpha-Phenylethyl)acrylamide;N-[(s)-1-phenylethyl] acrylamide;MFCD09910365;N-[(S)-alpha-Methylbenzyl]acrylamide;AKOS017390799;GP-0415;L-N-(ALPHA-PHENYLETHYL) ACRYLAMIDE;CS-0357498;A1-35368;Z1165166436

Chemical Property of N-((S)-1-phenylethyl)acrylamide

Chemical Property:

• PSA: 32.59000
• LogP: 2.89010
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 175.099714038
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

N-[(1S)-1-phenylethyl]prop-2-enamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)NC(=O)C=C
• Isomeric SMILES: C[C@@H](C1=CC=CC=C1)NC(=O)C=C

Technology Process of N-((S)-1-phenylethyl)acrylamide

There total 1 articles about N-((S)-1-phenylethyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-1-phenyl-ethylamine (2627-86-3) + acryloyl chloride (814-68-6,25189-84-8) → (S)-N-isopropyl-N-(1-phenylethyl)acrylamide (19035-71-3)

Guidance literature:

With TEA; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jo0344687

Reference yield: 95.0%

(S)-N-isopropyl-N-(1-phenylethyl)acrylamide (19035-71-3) → N,N'-bis-((S)-1-phenyl-ethyl)-fumaramide (7683-78-5)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; Heating;

DOI:10.1016/j.jorganchem.2005.07.116

Reference yield: 84.0%

N-chloro-4-methylbenzenesulfonamide (144-86-5) + (S)-N-isopropyl-N-(1-phenylethyl)acrylamide (19035-71-3) → (R)-2-Hydroxy-N-((S)-1-phenyl-ethyl)-3-(toluene-4-sulfonylamino)-propionamide

Guidance literature:

With K2; In water; tert-butyl alcohol; at 20 ℃;

DOI:10.1016/j.tetasy.2005.08.052

upstream raw materials:

(S)-1-phenyl-ethylamine

acryloyl chloride

Downstream raw materials:

N-Hydroxymethyl-N-((S)-1-phenyl-ethyl)-acrylamide

(5R)-1-(4-methylphenyl)-3-methoxycarbonyl-5-{N-[(S)-1-phenylethyl]amino}carbonyl-4,5-dihydropyrazole

(5S)-1-(4-methylphenyl)-3-methoxycarbonyl-5-{N-[(S)-1-phenylethyl]amino}carbonyl-4,5-dihydropyrazole

(S)-N-(1-phenylethyl)-3-(phenylthio)propanamide