2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE

Base Information

• Chemical Name: 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE
• CAS No.: 1904-65-0
• Molecular Formula: C8H10N2
• Molecular Weight: 134.181
• Hs Code.: 2933990090
• Mol file: 1904-65-0.mol

Synonyms:1,2,3,4-Tetrahydro-chinazolin;1,2,3,4-Tetrahydro-carbazol-9-carbonsaeure-amid;1,2,3,4-Tetrahydro-9H-carbazole-9-carboxamide;tetrahydroquinazoline;1,2,3,4-tetrahydro-quinazoline;1,2,3,4-Tetrahydrocarbazol-N-carboxamid;1,2,3,4-tetrahydro-carbazole-9-carboxylic acid amide;

Chemical Property of 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE

Chemical Property:

• PSA: 24.06000
• LogP: 1.66850

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE

There total 13 articles about 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-amino-1-benzylamine (4403-69-4) → 1,2,3,4-tetrahydroquinazoline (1904-65-0)

Guidance literature:

With potassium carbonate; In chloroform; Inert atmosphere;

DOI:10.1021/ol3029912

Reference yield: 89.0%

quinazoline (253-82-7) → 1,2,3,4-tetrahydroquinazoline (1904-65-0)

Guidance literature:

With hydrogen; In toluene; at 120 ℃; under 25858.1 Torr; Autoclave;

DOI:10.1002/cctc.201900367

Reference yield:

quinazoline (253-82-7) → 3,4-dihydroquinazoline (1904-64-9) + 1,2,3,4-tetrahydroquinazoline (1904-65-0)

Guidance literature:

With hydrogen; at 25 ℃; for 24h; under 3750.38 Torr;

DOI:10.1039/d0ra09981c

upstream raw materials:

quinazoline

3,4-dihydroquinazoline

quinazoline-N-oxide

1,2-dihydro-quinazoline

Downstream raw materials:

3-(2-iodobenzyl)-1,2,3,4-tetrahydroquinazoline

3-benzyl-1,2,3,4-tetrahydro-quinazoline

quinazoline

Refernces

• 1、 álvarez, Eleuterio,Hernández-Juárez, Martín,López-Serrano, Joaquín,Paneque, Margarita,Rendón, Nuria,Sánchez, Práxedes,Santos, Laura L.,Suárez, Andrés. "Hydrogenation/dehydrogenation of N-heterocycles catalyzed by ruthenium complexes based on multimodal proton-responsive CNN(H) pincer ligands". supporting information. p. 9583 - 9587. Retrieved 2020/07/30.
• 2、 Jaiswal, Garima,Subaramanian, Murugan,Sahoo, Manoj K.,Balaraman, Ekambaram. "A Reusable Cobalt Catalyst for Reversible Acceptorless Dehydrogenation and Hydrogenation of N-Heterocycles". . p. 2449 - 2457. Retrieved 2019/05/10.