4-Bromophthalazin-1(2H)-one

Base Information

Chemical Name:4-Bromophthalazin-1(2H)-one
CAS No.:19064-73-4
Molecular Formula:C8H5BrN2O
Molecular Weight:225.044
Hs Code.:2933990090
Mol file:19064-73-4.mol

Synonyms:1-Phthalazinol,4-bromo;4-bromophthalazin-1(2H)-one;4-Brom-2H-phthalazin-1-on;1-Brom-4-oxo-3,4-dihydro-phthalazin;1-Bromo-phthalazin-4-one;1(2H)-Phthalazinone,4-bromo;

Suppliers and Price of 4-Bromophthalazin-1(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Bromo-1(2H)-phthalazinone
100mg
$ 45.00

Crysdot
4-Bromophthalazin-1(2H)-one 95+%
1g
$ 257.00

Chemenu
4-Bromophthalazin-1(2H)-one 95%
1g
$ 243.00

Alichem
4-Bromophthalazin-1(2H)-one
1g
$ 260.00

AK Scientific
4-Bromophthalazin-1(2H)-one
1g
$ 193.00

AccelPharmtech
4-bromo-1(2H)-Phthalazinone 97.00%
25G
$ 4010.00

AccelPharmtech
4-bromo-1(2H)-Phthalazinone 97.00%
1G
$ 1940.00

Total 8 raw suppliers

Chemical Property of 4-Bromophthalazin-1(2H)-one

Chemical Property:

Melting Point:273 °C
PKA:10.58±0.40(Predicted)
PSA：46.01000
Density:1.82±0.1 g/cm3(Predicted)
LogP:2.09790
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-1(2H)-phthalazinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-Bromo-1(2H)-phthalazinone has been used in the synthesis of Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase; novel proteasome inhibitors based on phthalazinone scaffold

Technology Process of 4-Bromophthalazin-1(2H)-one

There total 7 articles about 4-Bromophthalazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1445-69-8
2,3-dihydrophthalazine-1,4-dione

: 19064-73-4
4-bromo-2H-phthalazin-1-one

Guidance literature:: 2,3-dihydrophthalazine-1,4-dione; With phosphorus(V) oxybromide; In 1,2-dichloro-ethane; for 12h; Reflux;

With acetic acid; at 100 ℃; for 2h;
DOI:10.1002/chem.201601499

Reference yield: 79.0%

: 119-39-1
phthalazone

: 19064-73-4
4-bromo-2H-phthalazin-1-one

Guidance literature:: phthalazone; With potassium carbonate; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

With benzyltrimethylazanium tribroman-2-uide; In N,N-dimethyl-formamide; at 40 ℃; for 5h; regioselective reaction; Inert atmosphere;
DOI:10.1021/acs.joc.5b02652