1,4-dibromophthalazine

Base Information

• Chemical Name: 1,4-dibromophthalazine
• CAS No.: 3660-90-0
• Molecular Formula: C₈H₄Br₂N₂
• Molecular Weight: 287.941
• Hs Code.: 2933998090
• Mol file: 3660-90-0.mol

Synonyms:1,4-dibromophthalazine

Chemical Property of 1,4-dibromophthalazine

Chemical Property:

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

1,4-Dibromophthalazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-dibromophthalazine

There total 5 articles about 1,4-dibromophthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,3-dihydrophthalazine-1,4-dione (1445-69-8) → 1,4-dibromophthalazine (3660-90-0)

Guidance literature:

With phosphorus pentabromide; at 140 ℃; Sealed tube;

Reference yield:

phthalic anhydride (85-44-9) → 1,4-dibromophthalazine (3660-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 80 °C

2: phosphorus pentabromide / 1,2-dichloro-ethane / 48 h / Reflux

With phosphorus pentabromide; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm101346r

Reference yield:

2,3-dihydrophthalazine-1,4-dione (1445-69-8) + phosphorus pentabromide (7789-69-7) → 1,4-dibromophthalazine (3660-90-0) + 4-bromo-2H-phthalazin-1-one (19064-73-4)

Guidance literature:

In 1,2-dichloro-ethane; for 48h; Heating / reflux;

upstream raw materials:

2,3-dihydrophthalazine-1,4-dione

phosphorus pentabromide

phthalic anhydride

Refernces

• 1、 Chen, Shi-Wu,Hao, Shu-Yi,Mou, Hong-Xia,Wang, Shuai,Xu, Yu,Zhang, Xiu-Juan. "The synthesis and anti‐tumour properties of novel 4-substituted phthalazinones as Aurora B kinase inhibitors". . . Retrieved 2020/09/22.
• 2、 -. "ORGANIC COMPOUND AND LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DIODE DISPLAY DEVICE USING THE SAME". Paragraph 0256; 0257-0259. . Retrieved 2018/01/13.