Chloro[3-(dimethylamino)propyl]magnesium

Base Information

• Chemical Name: Chloro[3-(dimethylamino)propyl]magnesium
• CAS No.: 19070-16-7
• Molecular Formula: C5H12ClMgN
• Molecular Weight: 145.915
• European Community (EC) Number: 925-734-7
• Mol file: 19070-16-7.mol

Synonyms:19070-16-7;CHLORO[3-(DIMETHYLAMINO)PROPYL]MAGNESIUM;Magnesium, chloro[3-(dimethylamino)propyl]-;[3-(chloromagnesio)propyl]dimethylamine;magnesium;N,N-dimethylpropan-1-amine;chloride;154034-91-0;Magnesium chloride 3-(dimethylamino)propan-1-ide (1/1/1);SCHEMBL1215;NDYLAABPGFMVIY-UHFFFAOYSA-M;3-Dimethylaminopropylmagnesiumchlorid;dimethylaminopropyl magnesium chloride;MFCD09955106;3-dimethylaminopropylmagnesium chloride;AB55603;3-dimethylaminopropyl magnesium chloride;3-(Dimethylamino)propylmagnesium chloride;N,N-dimethylaminopropylmagnesium chloride;3-N,N-Dimethylaminopropylmagnesium Chloride;3-(N,N-dimethylamino)propylmagnesium chloride

Chemical Property of Chloro[3-(dimethylamino)propyl]magnesium

Chemical Property:

• PSA: 3.24000
• LogP: -2.22380
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 145.0508688
• Heavy Atom Count: 8
• Complexity: 33.6

Purity/Quality:

98%Min ^*data from raw suppliers

chloro[3-(dimethylamino)propyl]magnesium >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC[CH2-].[Mg+2].[Cl-]

Technology Process of Chloro[3-(dimethylamino)propyl]magnesium

There total 8 articles about Chloro[3-(dimethylamino)propyl]magnesium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(Dimethylamino)propyl chloride (109-54-6) → 3-(N,N-dimethylamino)propylmagnesium chloride (19070-16-7)

Guidance literature:

With ethyl bromide; iodine; magnesium; In tetrahydrofuran; at 70 ℃; for 0.25h;

3-(Dimethylamino)propyl chloride; In tetrahydrofuran; at 68 - 70 ℃; Heating / reflux;

Reference yield:

3-(dimethylamino)propyl chloride hydrochloride (5407-04-5) → 3-(N,N-dimethylamino)propylmagnesium chloride (19070-16-7)

Guidance literature:

3-(dimethylamino)propyl chloride hydrochloride; With potassium hydroxide; In water; at 0 - 5 ℃;

With iodine; magnesium; In tetrahydrofuran; at 100 - 110 ℃; for 4h; Reflux;

Reference yield:

ammonium chloride + 3-(Dimethylamino)propyl chloride (109-54-6) + 11-oxo-2-<2-<(triphenylmethyl)oxy>ethyl>-6,11-dihydroxydibenzoxepin (113836-41-2) → 3-(N,N-dimethylamino)propylmagnesium chloride (19070-16-7)

Guidance literature:

With magnesium; 1,1-Dibromoethane; In tetrahydrofuran;

upstream raw materials:

3-(Dimethylamino)propyl chloride

11-oxo-2-<2-<(triphenylmethyl)oxy>ethyl>-6,11-dihydroxydibenzoxepin

2-(4,4-dimethyl-2-oxazolin-2-yl)-11-oxo-6,11-dihydrodibenzoxepin

10,11-dihydro-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cyclohepten-5-one

Downstream raw materials:

N,N-dimethyl-3-(5H-dibenzo[a,d]cyclohepten-5-yl)-propylamine

4,4-diethoxy-N,N-dimethyl-1-butanamine

N¹,N¹,N⁴,N⁴-Tetramethyl-1-phenyl-butane-1,4-diamine

(4S,5S)-5-(3-Dimethylamino-propyl)-4-hydroxy-4-phenylethynyl-cyclohex-2-enone

Refernces

Potential psychotropic and anthistamine agents: 1- and 3-alkyl-9-(3-dimethylaminopropylidene)- thioxanthenes and 3-alkyl-11-piperazino-10,11-dihydrodibenzo[b,f]thiepins

10.1135/cccc19823134

The research explores the synthesis and pharmacological properties of various thioxanthene and dibenzo[b,f]thiepin derivatives. The study involves the use of chemicals such as 3-methylthiophenol, 3-ethylthiophenol, 2-iodobenzoic acid, (2-iodophenyl)acetic acid, potassium hydroxide, copper, sulfuric acid, polyphosphoric acid, 3-dimethylaminopropylmagnesium chloride, and various piperazine derivatives. These chemicals are used in a series of reactions to produce compounds with potential antihistamine and psychotropic activities. The synthesized compounds are tested for their pharmacological effects, including antihistamine activity, central depressant effects, cataleptic activity, and antireserpine activity. The research aims to investigate the impact of substituents in unusual positions on the pharmacological profiles of these compounds, with potential applications in treating conditions like gastric hyperacidity, ulcers, and central nervous system disorders.