4-(Thiophen-3-yl)pyrimidine

Base Information

Chemical Name:4-(Thiophen-3-yl)pyrimidine
CAS No.:19084-28-7
Molecular Formula:C₈H₆N₂S
Molecular Weight:162.215
Hs Code.:
DSSTox Substance ID:DTXSID501313873
Mol file:19084-28-7.mol

Synonyms:4-(Thiophen-3-yl)pyrimidine;19084-28-7;4-thiophen-3-ylpyrimidine;4-thien-3-ylpyrimidine;4-thiophen-3-yl-pyrimidine;4-(3-Thienyl)pyrimidine;3-(4-pyrimidyl)thiophene;SCHEMBL1445303;DTXSID501313873;AKOS006277696;SB56285;AI-942/25034501

Suppliers and Price of 4-(Thiophen-3-yl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(Thiophen-3-yl)pyrimidine 97%
1g
$ 556.00

Alichem
4-(Thiophen-3-yl)pyrimidine
1g
$ 562.00

Total 4 raw suppliers

Chemical Property of 4-(Thiophen-3-yl)pyrimidine

Chemical Property:

PSA：0.00000
LogP:0.00000
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:162.02516937
Heavy Atom Count:11
Complexity:129

Purity/Quality:

99% ^*data from raw suppliers

4-(Thiophen-3-yl)pyrimidine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CN=CN=C1C2=CSC=C2

Technology Process of 4-(Thiophen-3-yl)pyrimidine

There total 4 articles about 4-(Thiophen-3-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 6313-33-3
formamidine hydrochloride

: 79571-33-8
3-dimethylamino-1-(thien-3-yl)-2-propen-1-one

: 19084-28-7
4-(thiophen-3-yl)pyrimidine

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 80 ℃;

Reference yield: 73.0%

: 79571-33-8
3-(dimethylamino)-1-(thiophen-3-yl)prop-2-en-1-one

: 6313-33-3
formamidine hydrochloride

: 19084-28-7
4-(thiophen-3-yl)pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 96h;
DOI:10.1021/acs.jmedchem.5b00424

Reference yield:

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 19084-28-7
4-(thiophen-3-yl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 18 h / Reflux

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 96 h / 80 °C

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00424