thiophen-3(2H)-one

Base Information

• Chemical Name: thiophen-3(2H)-one
• CAS No.: 19090-02-9
• Molecular Formula: C4H4OS
• Molecular Weight: 100.141
• Hs Code.: 2934999090
• Mol file: 19090-02-9.mol

Synonyms:3(2H)-Thiophenone;THIOPHEN-3(2H)-ONE;.thiophen-3-one;.Thiophen-3-on;.thiofuran-3-one;

Chemical Property of thiophen-3(2H)-one

Chemical Property:

• PSA: 42.37000
• LogP: 0.81600

Purity/Quality:

Thiophen-3(2H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of thiophen-3(2H)-one

There total 5 articles about thiophen-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

isopropylidene <1-(methylthio)ethylidene>malonate (123773-67-1) → thiophen-3(2H)-one (19090-02-9)

Guidance literature:

at 625 ℃; under 0.001 Torr;

DOI:10.1039/c39900000375

Reference yield: 47.0%

3-diethylcarbamoyloxythiophene + methyl iodide (74-88-4) → thiophen-3(2H)-one (19090-02-9) + 2-methyl-3-diethylcarbamoyloxythiophene

Guidance literature:

3-diethylcarbamoyloxythiophene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -30 ℃; for 2h;

methyl iodide; In tetrahydrofuran; hexane; at -30 - 20 ℃; for 1.66667h;

DOI:10.3987/COM-13-S(S)91

Reference yield:

3-S-hydroxythiophene (17236-59-8) → thiophen-3(2H)-one (19090-02-9)

Guidance literature:

Equilibrium constant;

DOI:10.1016/S0040-4039(00)84773-5

upstream raw materials:

3-S-hydroxythiophene

3-methoxy-thiophene

isopropylidene <1-(methylthio)ethylidene>malonate

3-<(Trimethylsilyl)oxy>thiophene

Downstream raw materials:

3-S-hydroxythiophene

3-methoxy-thiophene

3-Bromothiophene

Refernces

• 1、 Hunter,McNab. "Simple 3-hydroxythiophenes [thiophen-3(2H)-ones]". . p. 375 - 376. Retrieved 2007/10/02.
• 2、 Capon, Brian,Kwok, Fu-Chiu. "REVERSIBLE CARBON PROTONATION IN THE HYDROLYSIS OF HETEROCYCLIC ENOL METHYL ETHERS". . p. 69 - 76. Retrieved 2007/10/02.