Oxiranecarboxylic acid, 2-(6-hydroxyhexyl)-, ethyl ester, (2R)-

Base Information

• Chemical Name: Oxiranecarboxylic acid, 2-(6-hydroxyhexyl)-, ethyl ester, (2R)-
• CAS No.: 191412-56-3
• Molecular Formula: C11H20O4
• Molecular Weight: 216.277
• Mol file: 191412-56-3.mol

Synonyms:Oxiranecarboxylic acid,2-(6-hydroxyhexyl)-,ethyl ester,(2R);

Chemical Property of Oxiranecarboxylic acid, 2-(6-hydroxyhexyl)-, ethyl ester, (2R)-

Chemical Property:

• Boiling Point: 293.6±15.0 °C(Predicted)
• PSA: 59.06000
• Density: 1.092±0.06 g/cm3(Predicted)
• LogP: 1.26130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxiranecarboxylic acid, 2-(6-hydroxyhexyl)-, ethyl ester, (2R)-

There total 1 articles about Oxiranecarboxylic acid, 2-(6-hydroxyhexyl)-, ethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-6-benzyloxyhexane (54247-27-7) → (R)-2-(6-Hydroxy-hexyl)-oxirane-2-carboxylic acid ethyl ester (191412-56-3)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) NaH

2: 100 percent / aq. KOH / methanol / 5 h / Heating

3: 83 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 2 h / 0 °C

4: 100 percent / aq. KOH / methanol / 10 h / Heating

5: 87 percent / NBS / dimethylformamide / 24 h / Ambient temperature

6: 6N aq. HCl / 12 h / Heating

7: diethyl ether

8: 98 percent / K₂CO₃ / 6 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; diethyl cyanophosphonate; sodium hydride; potassium carbonate; triethylamine; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(97)00105-5

Reference yield: 94.0%

4-chloro-phenol (106-48-9,82344-39-6) + (R)-2-(6-Hydroxy-hexyl)-oxirane-2-carboxylic acid ethyl ester (191412-56-3) → (R)-(+)-etomoxir (124083-20-1,828934-40-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1016/S0957-4166(97)00105-5

upstream raw materials:

1-bromo-6-benzyloxyhexane

Downstream raw materials:

(R)-(+)-etomoxir