Chemical Property of R-(+)-Etomoxir
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:32-34°C
- Boiling Point:405°Cat760mmHg
- Flash Point:142.6°C
- PSA：48.06000
- Density:1.163g/cm3
- LogP:4.00140
- Storage Temp.:Refrigerator
- Solubility.:≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming
- XLogP3:4.3
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:11
- Exact Mass:326.1284869
- Heavy Atom Count:22
- Complexity:342
- Purity/Quality:
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99%, *data from raw suppliers
R-(+)-Etomoxir *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCOC(=O)C1(CO1)CCCCCCOC2=CC=C(C=C2)Cl
- Isomeric SMILES:CCOC(=O)[C@]1(CO1)CCCCCCOC2=CC=C(C=C2)Cl
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Description
Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα. An off-target effect has been demonstrated at high concentrations of etomoxir on Coenzyme-A (CoA) metabolism.
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Uses
An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug
