6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone

Base Information

• Chemical Name: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone
• CAS No.: 192187-32-9
• Molecular Formula: C22H13Cl2NO2
• Molecular Weight: 394.257
• European Community (EC) Number: 606-261-2
• ChEMBL ID: CHEMBL576445
• DSSTox Substance ID: DTXSID501201896
• Mol file: 192187-32-9.mol

Synonyms:192187-32-9;6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone;6-(4-chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one;CHEMBL576445;SCHEMBL1538310;ZLYWVUYGARBCQN-UHFFFAOYSA-N;DTXSID501201896;6-(4-Chloro-benzoyl)-4-(3-chloro-phenyl)-1H-quinolin-2-one

Chemical Property of 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• XLogP3: 5.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 393.0323340
• Heavy Atom Count: 27
• Complexity: 611

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)C2=CC(=O)NC3=C2C=C(C=C3)C(=O)C4=CC=C(C=C4)Cl

Technology Process of 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone

There total 17 articles about 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(3-chlorophenyl)-6-(4-chlorobenzyl)-2-quinolinone → R101763 (192187-32-9)

Guidance literature:

With pyridine; tert.-butylhydroperoxide; iodine; In water; at 80 ℃; Sealed tube; Inert atmosphere;

DOI:10.1021/ol503292p

Reference yield: 93.0%

6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-3,4-dihydro-2(1H)-quinolinone (192187-31-8) → R101763 (192187-32-9)

Guidance literature:

With bromobenzene; bromine; at 160 ℃; for 16h;

DOI:10.1002/ejoc.200300538

Reference yield: 87.0%

N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide (405548-67-6) → R101763 (192187-32-9)

Guidance literature:

With potassium tert-butylate; In 1,2-dimethoxyethane; at 20 ℃; for 3h;

DOI:10.1002/ejoc.200300538

upstream raw materials:

N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide

(4-chlorophenyl)-[4-(3-chlorophenyl)-2-methoxyquinolin-6-yl]methanone

6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-3,4-dihydro-2(1H)-quinolinone

(4-Chlorophenyl)(4-nitrophenyl)methanone

Downstream raw materials:

6-(4-Chloro-benzoyl)-4-(3-chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin-2-one

[2-chloro-4(3-chlorophenyl)-6-quinolinyl](4-chlorophenyl)-methanone hydrochloride

5-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-imidazol[1,2-a]quinoline-7-methanol

(4-chloro-phenyl)-[5-(3-chloro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol