4-(Benzofuran-2-yl)anisole

Base Information

• Chemical Name: 4-(Benzofuran-2-yl)anisole
• CAS No.: 19234-04-9
• Molecular Formula: C15H12O2
• Molecular Weight: 224.259
• Hs Code.: 2932990090
• Mol file: 19234-04-9.mol

Synonyms:benzofuran 2-(4'-methoxybenzoyl)benzofuran;2-p-methoxyphenylbenzofuran;2-(p-methoxyphenyl)benzofuran;2-(4-methoxy-phenyl)-benzo[b]furan;2-p-methoxyphenyl-benzofuran;2-(4-methoxyphenyl)benzo[b]furan;

Chemical Property of 4-(Benzofuran-2-yl)anisole

Chemical Property:

• PSA: 22.37000
• LogP: 4.10840

Purity/Quality:

2-(4-METHOXYPHENYL)BENZOFURAN 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(Benzofuran-2-yl)anisole

There total 148 articles about 4-(Benzofuran-2-yl)anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-bromo-4-methoxy-benzene (104-92-7) + benzofuran-2-boronic acid (98437-24-2) → 2-(p-methoxyphenyl)-benzo[b]furan (19234-04-9)

Guidance literature:

With tri-tert-butyl phosphine; palladium diacetate; potassium hydroxide; In tetrahydrofuran; water; at 24 ℃; for 0.0833333h; Flow reactor;

DOI:10.1002/chem.201201579

Reference yield: 100.0%

1-methoxy-2-[2-(4-methoxyphenyl)ethynyl]benzene (31766-64-0) → 2-(p-methoxyphenyl)-benzo[b]furan (19234-04-9)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 130 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmc.2013.07.002

Reference yield: 99.0%

2-Iodophenol (533-58-4) + 4-methoxyphenylacetylen (768-60-5) → 2-(p-methoxyphenyl)-benzo[b]furan (19234-04-9)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); tetraphosphine N,N,N′,N′-tetra(diphenylphosphinomethyl)-pyridine-2,6-diamine; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4cc00815d

upstream raw materials:

1-benzofurane

1-bromo-4-methoxy-benzene

para-iodoanisole

1-(4-methoxy-phenyl)-2-phenoxy-ethanone

Downstream raw materials:

2-(4-hydroxyphenyl)benzo[b]furan

3-p-chlorobenzoyl-2-p-methoxyphenylbenzofuran

C₂₂H₁₅FO₃

C₂₂H₁₅FO₃

Refernces

• 1、 Taylor, Rachel H.,Felpin, Francois-Xavier. "Suzuki-Miyaura reactions of arenediazonium salts catalyzed by Pd(0)/C. One-pot chemoselective double cross-coupling reactions". . p. 2911 - 2914. Retrieved 2007.
• 2、 Hegde, Rajeev V.,Ong, Tiow-Gan,Ambre, Ram,Jadhav, Arvind H.,Patil, Siddappa A.,Dateer, Ramesh B.. "Regioselective Direct C2 Arylation of Indole, Benzothiophene and Benzofuran: Utilization of Reusable Pd NPs and NHC-Pd@MNPs Catalyst for C–H Activation Reaction". . p. 1397 - 1405. Retrieved 2020/10/02.
• 3、 Liu, Juyan,Tian, Miaomiao,Li, Ankun,Ji, Liangshuo,Qiu, Di,Zhao, Xia. "Acid-promoted selective synthesis of trifluoromethylselenolated benzofurans with Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate". supporting information. . Retrieved 2021/02/01.