Benzoic acid, 2-(1-pyrrolidinyl)-, ethyl ester

Base Information

• Chemical Name: Benzoic acid, 2-(1-pyrrolidinyl)-, ethyl ester
• CAS No.: 192817-77-9
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.28000
• Mol file: 192817-77-9.mol

Synonyms:ethyl 2-pyrrolidinobenzoate;Benzoic acid,2-(1-pyrrolidinyl)-,ethyl ester;

Chemical Property of Benzoic acid, 2-(1-pyrrolidinyl)-, ethyl ester

Chemical Property:

• PSA: 29.54000
• LogP: 2.52850

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-(1-pyrrolidinyl)-, ethyl ester

There total 4 articles about Benzoic acid, 2-(1-pyrrolidinyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 2-(1-pyrrolidinyl)-1-cyclohexene-1-carboxylate (21328-43-8) → ethyl 2-pyrrolidinobenzoate (192817-77-9)

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; at 0 - 25 ℃;

DOI:10.1016/S0040-4039(02)00380-5

Reference yield: 71.0%

pyrrolidine (123-75-1) + 2-fluoro-benzoic acid ethyl ester (443-26-5) → ethyl 2-pyrrolidinobenzoate (192817-77-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Heating;

DOI:10.1016/S0040-4020(97)00448-1

Reference yield: 62.0%

ethyl (E)-3-(pyrrolidin-1-yl)hepta-2,6-dienoate → ethyl 2-pyrrolidinobenzoate (192817-77-9)

Guidance literature:

With copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.151659

upstream raw materials:

pyrrolidine

2-fluoro-benzoic acid ethyl ester

ethyl 2-(1-pyrrolidinyl)-1-cyclohexene-1-carboxylate

2-Fluorobenzoyl chloride

Downstream raw materials:

[2-Oxo-2-(2-pyrrolidin-1-yl-phenyl)-ethyl]-phosphonic acid dimethyl ester

dimethyl 1-diazo-2-oxo-2-(2-pyrrolidinophenyl)ethylphosphonate

Refernces

• 1、 Kishimoto, Ryo,Mikami, Shunya,Okada, Sho,Takabatake, Tetsuhiko,Toyota, Masahiro. "Pd(OAc)2-catalyzed one-pot preparation of anthranilates from acyclic unsaturated β-enamino esters". . . Retrieved 2020/02/22.
• 2、 Chantegrel,Deshayes,Faure. "Tandem Wolff rearrangement-'tert-amino effect' sequence: Synthesis of 2-oxoindolinium enolate and 1H-2-benzopyrane derivatives". . p. 7859 - 7862. Retrieved 2007/10/02.