4-(4-TRIFLUOROMETHYLBENZYL)PIPERIDINE

Base Information

• Chemical Name: 4-(4-TRIFLUOROMETHYLBENZYL)PIPERIDINE
• CAS No.: 192990-03-7
• Molecular Formula: C13H16F3N
• Molecular Weight: 243.272
• Mol file: 192990-03-7.mol

Synonyms:4-(4-TRIFLUOROMETHYLBENZYL)PIPERIDINE;4-(4-Trifluoromethylbenzyl)piperidine HCl;4-(4-(TRIFLUOROMETHYL)BENZYL)PIPERIDINE;

Chemical Property of 4-(4-TRIFLUOROMETHYLBENZYL)PIPERIDINE

Chemical Property:

• Boiling Point: 291.3±35.0 °C(Predicted)
• PKA: 10.52±0.10(Predicted)
• PSA: 12.03000
• Density: 1.135±0.06 g/cm3(Predicted)
• LogP: 3.57630
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

4-(4-(Trifluoromethyl)benzyl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-TRIFLUOROMETHYLBENZYL)PIPERIDINE

There total 1 articles about 4-(4-TRIFLUOROMETHYLBENZYL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-[4-(trifluoromethyl)benzyl]piperidine (192990-03-7)

Guidance literature:

Reference yield: 98.3%

4-Nitrophenyl chloroformate (7693-46-1) + 4-[4-(trifluoromethyl)benzyl]piperidine (192990-03-7) → 4-nitrophenyl 4-(4-(trifluoromethyl)benzyl)piperidine-1-carboxylate

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

Reference yield: 62.0%

N-(3-chloropropyl)-N-(3,4-dichlorophenyl)-1-(methylsulfonyl)piperidine-4-carboxamide (333986-31-5) + 4-[4-(trifluoromethyl)benzyl]piperidine (192990-03-7) → N-(3,4-Dichlorophenyl)-1-(methylsulfonyl)-N-(3-{4-[4-(trifluoromethyl)benzyl]-1-piperidinyl}propyl)-4-piperidinecarboxamide

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; at 80 ℃; for 13h;

DOI:10.1016/j.bmc.2004.10.013

Downstream raw materials:

1-(3-Butynyl)-4-[(4-trifluoromethylphenyl)methyl]piperidine