7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE HYDROCHLORIDE
• CAS No.: 193001-44-4
• Molecular Formula: C16H13ClN2O2.ClH
• Molecular Weight: 337.20100
• Hs Code.: 2933990090
• Mol file: 193001-44-4.mol

Synonyms:7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride;

Chemical Property of 7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE HYDROCHLORIDE

Chemical Property:

• PSA: 44.24000
• LogP: 4.67280

Purity/Quality:

97% ^*data from raw suppliers

7-Benzyloxy-4-chloro-6-methoxy-quinazolinehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE HYDROCHLORIDE

There total 10 articles about 7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one (179688-01-8) → 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (193001-44-4)

Guidance literature:

With thionyl chloride; trichlorophosphate; N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield: 60.0%

→ 7-benzyloxy-4-(3-hydroxy-4-methylanilino)-6-methoxyquinazoline (196603-79-9) + 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (193001-44-4)

Guidance literature:

Reference yield:

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one (179688-01-8) → 7-benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) + 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (193001-44-4)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide;

upstream raw materials:

7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one

2-amino-4-benzyloxy-5-methoxybenzamide

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one

4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

Downstream raw materials:

7-hydroxy-6-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline