2-(2-Fluoroethoxy)-5-iodobenzoic acid

Base Information

Chemical Name:2-(2-Fluoroethoxy)-5-iodobenzoic acid
CAS No.:193882-73-4
Molecular Formula:C9H8FIO3
Molecular Weight:310.064
Hs Code.:
DSSTox Substance ID:DTXSID30443547
Wikidata:Q82261429
Mol file:193882-73-4.mol

Synonyms:2-(2-fluoroethoxy)-5-iodobenzoic acid;193882-73-4;Benzoic acid, 2-(2-fluoroethoxy)-5-iodo-;DTXSID30443547;AKOS021315808;A1-05302

Suppliers and Price of 2-(2-Fluoroethoxy)-5-iodobenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Fluoroethoxy)-5-iodobenzoic acid

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:309.95022
Heavy Atom Count:14
Complexity:201

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1I)C(=O)O)OCCF

Technology Process of 2-(2-Fluoroethoxy)-5-iodobenzoic acid

There total 5 articles about 2-(2-Fluoroethoxy)-5-iodobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 193882-74-5
methyl 2-(2-fluoroethoxy)-5-iodobenzoate

: 193882-73-4
2-(2-fluoroethoxy)-5-iodobenzoic acid

Guidance literature:: methyl 2-(2-fluoroethoxy)-5-iodobenzoate; With sodium hydroxide; In methanol; water; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=5 - Ca. 6; Inert atmosphere;
DOI:10.1021/jm5001453

Reference yield:

: 4068-75-1
methyl 5-iodosalicylate

: 193882-73-4
2-(2-fluoroethoxy)-5-iodobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.89 g / K₂CO₃ / acetone / 18 h / 85 °C

2: NaOH / ethanol / 2.5 h / 95 °C

With sodium hydroxide; potassium carbonate; In ethanol; acetone;
DOI:10.1016/S0223-5234(97)81676-5

Reference yield:

: 119-30-2
2-hydroxy-5-iodobenzoic acid

: 193882-73-4
2-(2-fluoroethoxy)-5-iodobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: potassium carbonate / acetone / Reflux

3: water; sodium hydroxide / methanol / 20 °C

With sulfuric acid; water; potassium carbonate; sodium hydroxide; In methanol; acetone; 1: Fischer esterification;
DOI:10.1021/jm101323b