4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline

Base Information

• Chemical Name: 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline
• CAS No.: 196195-13-8
• Molecular Formula: C16H20ClN3O3
• Molecular Weight: 337.806
• DSSTox Substance ID: DTXSID30473889
• Wikidata: Q82303566
• Mol file: 196195-13-8.mol

Synonyms:196195-13-8;4-chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline;Quinazoline, 4-chloro-6-methoxy-7-[3-(4-morpholinyl)propoxy]-;SCHEMBL3530275;DTXSID30473889;OUJRTEVIUYGUQY-UHFFFAOYSA-N;AKOS025149597;4-chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline;4-chloro-7-(3-morpholinopropoxy)-6-methoxyquinazoline;4- chloro-6-methoxy-7-(3-morpholinopropoxy)quinazoline;4-Chloro-6-methoxy-7-(3-morpholin-4ylpropoxy)quinazoline;4-chloro-6-methoxy-7-(3-(4-morpholinyl)propoxy)quinazoline;4-chloro-6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinazoline

Chemical Property of 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 337.1193192
• Heavy Atom Count: 23
• Complexity: 358

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)Cl)OCCCN3CCOCC3

Technology Process of 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline

There total 2 articles about 4-Chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) + 7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one (179688-01-8) + phenol (108-95-2,27073-41-2) → 7-benzyloxy-6-methoxy-4-phenoxyquinazoline (193001-55-7) + 4-(3-((4-chloro-6-methoxyquinazolin-7-yl)oxy)propyl)morpholine (196195-13-8)

Guidance literature:

With thionyl chloride; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

→ 7-benzyloxy-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (193002-24-3) + 4-(3-((4-chloro-6-methoxyquinazolin-7-yl)oxy)propyl)morpholine (196195-13-8)

Guidance literature:

Reference yield: 95.0%

N-(tert-butoxycarbonyl)-1,4-phenylenediamine (71026-66-9) + 4-(3-((4-chloro-6-methoxyquinazolin-7-yl)oxy)propyl)morpholine (196195-13-8) → 4-(4-(N-Boc-amino)anilino)-6-methoxy-7-(3-morpholinopropoxy)quinazoline dihydrochloride

Guidance literature:

In isopropyl alcohol; for 3.5h; Heating / reflux;

upstream raw materials:

7-benzyloxy-4-chloro-6-methoxyquinazoline

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one

phenol

Downstream raw materials:

4-(7-benzyloxyoxindol-3-yl)-6-methoxy-7-(3-morpholinopropoxy)quinazoline

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