(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Base Information

Chemical Name:(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester
CAS No.:191786-74-0
Molecular Formula:C₃₉H₄₂F₆N₃O₁₀P
Molecular Weight:857.741
Hs Code.:

(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Synonyms:

Suppliers and Price of (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

There total 1 articles about (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 920-66-1
1,1,1,3',3',3'-hexafluoro-propanol

: 153809-40-6,153809-41-7,168752-56-5
5'-O-(4,4'-dimethoxytrityl)-N⁴-isobutyryl-2'-O-methylcytidine-3'-(methyl-N,N-diisopropylphosphonamidite)

: (S)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

: 191786-74-0
(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Guidance literature:: With pyridine; 1H-tetrazole; iodine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₃CN, room temperature, 3 min, 2.) THF, H₂O, room temperature, 20 min;
DOI:10.1080/07328319708001359

Reference yield:

: N-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 191786-74-0
(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

: C₅₄H₅₉N₈O₁₄P

: C₅₄H₅₉N₈O₁₄P

Guidance literature:: With 3-ethyl-3-pentanoxymagnesium chloride; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 60-65 deg C, 2.) THF, room temperature, 2 h;
DOI:10.1080/07328319708001359

Reference yield:

: N-{1-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-isobutyramide

: 191786-74-0
(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

: C₅₀H₆₁N₆O₁₅P

: C₅₀H₆₁N₆O₁₅P

Guidance literature:: With 3-ethyl-3-pentanoxymagnesium chloride; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 60-65 deg C, 2.) THF, room temperature, 2 h;
DOI:10.1080/07328319708001359