FMOC-D-LEU-CL

Base Information

• Chemical Name: FMOC-D-LEU-CL
• CAS No.: 198544-60-4
• Molecular Formula: C21H22ClNO3
• Molecular Weight: 371.85700
• Mol file: 198544-60-4.mol

Synonyms:((R)-1-Chlorocarbonyl-3-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester;

Chemical Property of FMOC-D-LEU-CL

Chemical Property:

• Boiling Point: 518.8±33.0 °C(Predicted)
• PKA: 10.36±0.46(Predicted)
• PSA: 55.40000
• Density: 1.213±0.06 g/cm3(Predicted)
• LogP: 5.09610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Fmoc-D-leucyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC-D-LEU-CL

There total 1 articles about FMOC-D-LEU-CL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-D-leucine (35661-60-0,126727-03-5,114360-54-2) → Fmoc-D-Leu-Cl (198544-60-4)

Guidance literature:

With thionyl chloride; In dichloromethane; for 2h; Heating;

DOI:10.1021/jo991589r

Reference yield: 85.0%

O-benzoyl-N-phenethylhydroxylamine (69424-54-0) + Fmoc-D-Leu-Cl (198544-60-4) → N-(2-phenylethyl)-N-(benzoyloxy)-Nα-Fmoc-D-leucinamide (264281-98-3)

Guidance literature:

With Carbonate buffer; In dichloromethane; water; at 20 ℃; pH=10.5;

DOI:10.1021/jo991589r

Reference yield:

Fmoc-D-Leu-Cl (198544-60-4) → Nα-amido[Nα-BOC-L-valinyl]-N-(2-phenylethyl)-N-(hydroxy)-D-leucinamide

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / carbonate buffer / CH₂Cl₂; H₂O / 20 °C / pH 10.5

2: 90 percent / NH₄OH / methanol / 0.5 h

3: diethylamine / dimethylformamide

4: 63 percent / DCC / CH₂Cl₂ / 20 °C

With ammonium hydroxide; Carbonate buffer; diethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Hydrolysis / 4: Condensation;

DOI:10.1021/jo991589r

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-D-leucine

Downstream raw materials:

N-(2-phenylethyl)-N-(benzoyloxy)-N_α-Fmoc-D-leucinamide

N-(2-phenylethyl)-N-(hydroxy)-N_α-Fmoc-D-leucinamide