2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Base Information

• Chemical Name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine
• CAS No.: 19959-77-4
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Hs Code.: 2933990090
• Mol file: 19959-77-4.mol

Synonyms:4-hydroxy-2-oxo-2H-chromene-3-carbonitrile;3-(2-pyridyl)-5-methyl-1H-pyrazole;2H-1-Benzopyran-3-carbonitrile,4-hydroxy-2-oxo;Coumarin,3-cyano-4-hydroxy-(6CI,7CI,8CI);3-methyl-5-(2-pyridyl)pyrazole;2-(5-methyl-1(2)H-pyrazol-3-yl)-pyridine;3-Cyan-4-hydroxy-cumarin;2-H-3-methyl-5-(2-pyridynyl)pyrazole;3-Cyano-4-hydroxycoumarin;2H-3-cyano-4-hydroxy-benzopyran-2-one;

Chemical Property of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Chemical Property:

• Melting Point: 113.0-116.5 °C(Solv: carbon tetrachloride (56-23-5))
• Boiling Point: 352.3±27.0 °C(Predicted)
• PKA: 11.92±0.10(Predicted)
• PSA: 41.57000
• Density: 1.172
• LogP: 1.78010
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Deuterated Chloroform, DMSO

Purity/Quality:

99.90% ^*data from raw suppliers

3-Methyl-5-(2-pyridyl)pyrazole ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methyl-5-(2-pyridyl)pyrazole is an intermediate in the synthesis of ligand-metal-chelate complexes.

Technology Process of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

There total 6 articles about 2-(5-Methyl-1H-pyrazol-3-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(2-pyridyl)-1-buten-3-one (99662-36-9) → 2-(5-methyl-1H-pyrazol-3-yl)pyridine (19959-77-4)

Guidance literature:

With tetrabutylammomium bromide; toluene-4-sulfonic acid hydrazide; sodium hydroxide; In water; at 80 ℃; for 10h; Air atmosphere;

DOI:10.1016/j.tet.2011.09.074

Reference yield: 70.0%

1-pyridin-2-yl-butane-1,3-dione (40614-52-6) → 2-(5-methyl-1H-pyrazol-3-yl)pyridine (19959-77-4)

Guidance literature:

With hydrazine hydrate; In methanol; water;

DOI:10.3184/030823409X402546

Reference yield:

(Z)-4-hydroxy-4-(pyridin-2-yl)but-3-en-2-one (1031694-63-9) → 2-(5-methyl-1H-pyrazol-3-yl)pyridine (19959-77-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1.5h; Yield given; Heating;

DOI:10.1021/ja982269c

upstream raw materials:

(Z)-4-hydroxy-4-(pyridin-2-yl)but-3-en-2-one

1-pyridin-2-yl-butane-1,3-dione

2-acetylpyridine

ethyl-2-picolinate

Refernces

• 1、 Yao, Haiyan,Guo, Quanping,Wang, Mengran,Wang, Rui,Xu, Zhaoqing. "Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors". . . Retrieved 2021/08/25.
• 2、 Wen, Jun,Fu, Yun,Zhang, Ruo-Yi,Zhang, Ji,Chen, Shan-Yong,Yu, Xiao-Qi. "A simple and efficient synthesis of pyrazoles in water". supporting information; experimental part. p. 9618 - 9621. Retrieved 2011/12/14.