40614-52-6

Usage

Main properties of 2-Acetoacetylpyridine

1. Molecular formula: C8H9NO2
2. Contains a keto group and an acetyl group
3. Used as a building block in the synthesis of pharmaceuticals and agrochemicals
4. Acts as a ligand in coordination chemistry
5. Forms stable complexes with metal ions
6. Studied for potential anti-cancer and anti-inflammatory properties

Specific content about 2-Acetoacetylpyridine

Chemical compound
Pyridine derivative
Used in synthesis of pharmaceuticals and agrochemicals
Forms stable complexes with metal ions
Potential anti-cancer and anti-inflammatory properties
Ligand in coordination chemistry.

Upstream product

• 2524-52-9 ethyl-2-picolinate 
• 67-64-1 acetone 
• 98-98-6 2-Picolinic acid 
• 1122-62-9 2-acetylpyridine 
• 141-78-6 ethyl acetate 
• 7647-01-0 hydrogenchloride 
• 10284-86-3 3-amino-1-[2]pyridyl-but-2-en-1-one 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 60-29-7 diethyl ether 
• 124-41-4 sodium methylate 

Downstream Products

• 108719-41-1 2-(5-methyl-2-phenyl-2H-pyrazol-3-yl)-pyridine 
• 6337-41-3 4-hydroxy-4-(pyridin-2-yl)butan-2-one 
• 180639-98-9 (C₉H₈NO₂)B(C₆H₅)2 
• 19959-77-4 2-(5-methyl-1H-pyrazol-3-yl)pyridine 
• 98-98-6 2-Picolinic acid 
• 67-64-1 acetone 
• 27305-70-0 methyl-3(5) α-pyridyl-5(3) pyrazole 
• 85903-37-3 3-Methyl-5-(2-pyridyl)isoxazole 

Relevant academic research and scientific papers

High efficiency electroluminescence of orange-red iridium(III) complexes for OLEDs with an EQE over 30%

In this study, three pyrazol-pyridine ligands, 2-(3-methyl-1H-pyrazol-5-yl)pyridine (mepzpy), 2-(3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridine (cf3pzpy), and 2-(3-phenyl-1H-pyrazol-5-yl)pyridine (phpzpy) were successfully synthesized for three orange-red iridium (III) complexes Ir1, Ir2, and Ir3, respectively, in which (2,6-bis(trifluoromethyl)pyridin-4-yl)isoquinoline (BTPIQ) was applied as main ligand. Their single crystals were obtained by vacuum sublimation. They showed distinct photoluminescent emissions at 583 nm with a shoulder peak at 624 nm, with high phosphorescence quantum yields of up to 89%. Organic light-emitting devices (OLEDs) with these complexes as emitters exhibits good performances. Especially, the device with Ir3 complex achieves the best performance with a maximum luminance of 24,188 cd m?2, and a highest external quantum efficiency of 30.65%. This research proved that Ir(III) complexes show highly enhanced performance by the modification of electro-donating benzene ring group into ancillary ligands, which also offers us an efficient strategy to obtain high efficiency orange-red Ir(III) complexes for OLEDs.

Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors

Based on a new pyrazole sulfonate synthetic method, a novel class of molecules with a basic structure of pyrazole N-aryl sulfonate have been designed and synthesized. The interest in conducting intensive research stems from quite evident anti-inflammatory effects exhibited by the compounds in preliminary animal experiments. A series of compounds were synthesized by different substitutions of the R1, R2, and R3 groups. Within the series, 4-iodophenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate and phenyl 5-methyl-3-(4-(trifluoromethyl) phenyl)-1H-pyrazole-1-sulfonate exhibited excellent anti-inflammatory activity (% inhibition of auricular edemas = 27.0 and 35.9, respectively); the in vivo analgesic activity of phenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate and 2-chlorophenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate was confirmed to be effective (inhibition ratio of writhing = 50.7% and 48.5% separately), and compounds phenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate, 4-iodophenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate and 2-chlorophenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate were identified as selective COX-2 inhibitors (SI = 455, 10,497 and >189 severally). In Acute Oral Toxicity assays conducted in vivo, the lethal dose 50 (LD50) of 4-iodophenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate and 2-chlorophenyl 5-methyl-3-(p-tolyl)-1H-pyrazole-1-sulfonate to mice was >2000 mg/kg BW.

Pyrazole compound containing N-aryl sulfonate and synthesis and application thereof

The invention discloses a pyrazole compound containing N-aryl sulfonate. A structural formula of the pyrazole compound is shown in the description. Proofed by pharmacological study, the pyrazole compound has the advantages that the activity of cyclooxygenase 2 is inhibited; the high-efficiency inhibition function on the generation of cyclooxygenase 2 due to inflammation mediums is realized, so that the pyrazole compound can be used as an active matter, and the prepared anti-inflammation medicine can be used for treating the inflammations, such as rheumatic arthritis and rheumatalgia, and the diseases and symptoms, such as fevers.

Highly efficient green electroluminescence of iridium(iii) complexes based on (1: H -pyrazol-5-yl)pyridine derivatives ancillary ligands with low efficiency roll-off

Four iridium(iii) complexes, namely Ir-me, Ir-cf3, Ir-py, and Ir-ph, were synthesized, in which 2-(4-trifluoromethyl)phenylpyridine (tfmppy) was used as the main ligand and 2-(3-methyl-1H-pyrazol-5-yl)pyridine (mepzpy), 2-(3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridine (cf3pzpy), 2,2′-(1H-pyrazole-3,5-diyl)dipyridine (pypzpy), and 2-(3-phenyl-1H-pyrazol-5-yl)pyridine (phpzpy) were applied as ancillary ligands, respectively. All complexes showed similar green light peaking at 494-499 nm with high phosphorescence quantum efficiency (0.76-0.82). The organic light-emitting diodes (OLEDs) with the structure of ITO/HATCN (hexaazatriphenylenehexacabonitrile) (5 nm)/TAPC (bis[4-(N,N-ditolylamino)-phenyl]cyclohexane, 50 nm)/Ir complexes (8 wt%): TCTA (4,4′,4′′-tri(9-carbazoyl)triphenylamine, 20 nm)/TmPyPB (1,3,5-tri[(3-pyridyl)-phen-3-yl]benzene, 40 nm)/LiF (1 nm)/Al (100 nm) displayed high current efficiency with low efficiency roll-off. Moreover, the device based on the Ir-me complex exhibited the best performances with a maximum luminance of 38 155 cd m-2, maximum current efficiency of 92 cd A-1, and a maximum external quantum efficiency of 28.90%. These results suggested that green Ir(iii) complexes were obtained by modification of the ppy ligand and rational introduction of (1H-pyrazol-5-yl)pyridine derivatives as the ancillary ligands for high efficient OLEDs.

Highly efficient bluish green organic light-emitting diodes of iridium(iii) complexes with low efficiency roll-off

Two novel iridium(iii) complexes Ir(BTBP)2mepzpy and Ir(BTBP)2phpzpy were successfully synthesized, in which 2′,6′-bis(trifluoromethyl)-2,4′-bipyridine (BTBP) was used as the main ligand, and 2-(3-methyl-1H-pyrazol-5-yl)pyridine (mep

Photoluminescence and electroluminescence of four orange-red and red organic iridium(III) complexes

Using 1-(4-(trifluoromethyl)phenyl)isoquinoline (tfmpiq) and 4-(4-(trifluoromethyl)phenyl) quinazoline (tfmpqz) as the main ligands and pyrazole pyridine derivatives (mepzpy: 2-(3-methyl-1H-pyrazol-5-yl)pyridine, cf3pzpy: 2-(3-(trifluoromethyl)-1H-pyrazol

Structure-reactivity relationships in the hydrogenation of carbon dioxide with ruthenium complexes bearing pyridinylazolato ligands

Pyridinylazolato (N-N') ruthenium(II) complexes of the type [(N-N')RuCl(PMe3)3] have been obtained in high yields by treating the corresponding functionalised azolylpyridines with [RuCl 2(PMe3)4] in the presence of a base. 15N NMR spectroscopy was used to elucidate the electronic influence of the substituents attached to the azolyl ring. The findings are in agreement with slight differences in the bond lengths of the ruthenium complexes. Furthermore, the electronic nature of the azolate moiety modulates the catalytic activity of the ruthenium complexes in the hydrogenation of carbon dioxide under supercritical conditions and in the transfer hydrogenation of acetophenone. DFT calculations were performed to shed light on the mechanism of the hydrogenation of carbon dioxide and to clarify the impact of the electronic nature of the pyridinylazolate ligands. Copyright

PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the composition

SUBSTITUTED 1-(THIAZOLYL)-AND 1-(ISOTHIAZOLYL)PYRAZOL-4-YLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS

The invention relates to 1-(thiazolyl)- and 1-(isothiazolyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R1, R2, R3, R4, R5, R6 and n are a

SUBSTITUTED 1-(DIAZINYL)PYRAZOL-4-YLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS

The invention relates to 1-(3-diazinyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R1, R2, R3, R4, R5, R6 and n are as defined in the spec