Glycine, N-methyl-N-phenyl-, methyl ester

Base Information

• Chemical Name: Glycine, N-methyl-N-phenyl-, methyl ester
• CAS No.: 20059-60-3
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol file: 20059-60-3.mol

Synonyms:Methyl N-methyl-N-phenylglycinate;methyl(methoxycarbonylmethyl)aniline;methyl N-methyl-N-phenylaminoacetate;N-Methyl-N-phenyl-glycin-methylester;N-methyl-N-phenyl-glycine methyl ester;Methylanilinoessigsaeure-methylester;

Chemical Property of Glycine, N-methyl-N-phenyl-, methyl ester

Chemical Property:

• PSA: 29.54000
• LogP: 1.29580

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-methyl-N-phenyl-, methyl ester

There total 11 articles about Glycine, N-methyl-N-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 2-iodoacetate (5199-50-8) + N-methylaniline (100-61-8) → N-methyl-N-p-phenylglycine methyl ester (20059-60-3)

Guidance literature:

With sodium acetate; In water; acetonitrile; at 90 ℃;

DOI:10.1021/ol401139m

Reference yield: 86.0%

N-methylaniline (100-61-8) + malonic acid dimethyl ester (108-59-8) → N-methyl-N-p-phenylglycine methyl ester (20059-60-3)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; acetonitrile; at 90 ℃; for 12h; Reagent/catalyst; Catalytic behavior;

DOI:10.1039/c5ob00109a

Reference yield: 84.0%

Malonic acid monomethyl ester (16695-14-0) + N-methylaniline (100-61-8) → N-methyl-N-p-phenylglycine methyl ester (20059-60-3)

Guidance literature:

With tert.-butylhydroperoxide; sodium acetate; tetra-(n-butyl)ammonium iodide; In water; acetonitrile; at 90 ℃; for 8h; Reagent/catalyst;

DOI:10.1021/ol401139m

upstream raw materials:

Dimethyl-phenylammonium-essigsaeure-betain

bromoacetic acid methyl ester

N-methylaniline

methyl diazoacetate

Downstream raw materials:

2-(N-methyl-N-phenylamino)acethydrazide

5-(phenyl)-1-methylindoline-2,3-dione

N-phenyl-N-methylglycine hydrochloride

2-(N-methyl-N-(4-iodophenyl)aminomethyl)-1,3,4-oxadiazole