PYRAZINE-2-CARBOXAMIDINE

Base Information

• Chemical Name: PYRAZINE-2-CARBOXAMIDINE
• CAS No.: 200928-43-4
• Molecular Formula: C₅H₆N₄
• Molecular Weight: 122.129
• Mol file: 200928-43-4.mol

Synonyms:Pyrazinecarboximidamide;pyrazin-2-carboximidamid;Pyrazine-2-carboxamidine;2-pyrazinecarboximidamide;

Chemical Property of PYRAZINE-2-CARBOXAMIDINE

Chemical Property:

• PSA: 75.65000
• LogP: 0.56070

Purity/Quality:

98%Min ^*data from raw suppliers

PYRAZINE-2-CARBOXAMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRAZINE-2-CARBOXAMIDINE

There total 1 articles about PYRAZINE-2-CARBOXAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-pyrazine carbonitrile (19847-12-2) → 2-carbamidinopyrazine (200928-43-4)

Guidance literature:

With ammonium chloride; In methanol;

Reference yield:

2-carbamidinopyrazine (200928-43-4) → 6-chloro-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine (461678-27-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tributyl-amine / 2 h / 170 °C

2: sodium hydroxide / toluene

3: trichlorophosphate / 6 h / 130 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C

With tributyl-amine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm5005623

Reference yield:

2-carbamidinopyrazine (200928-43-4) → 6-chloro-2-(pyrazin-2-yl)-N-(2,2,2-trifluoroethyl)-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine (849600-02-8)

Guidance literature:

Multi-step reaction with 4 steps

1: tributyl-amine / 2 h / 170 °C

2: sodium hydroxide / toluene

3: trichlorophosphate / 6 h / 130 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C

With tributyl-amine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm5005623

upstream raw materials:

2-pyrazine carbonitrile

Downstream raw materials:

6-chloro-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine

6-chloro-2-(pyrazin-2-yl)-N-(2,2,2-trifluoroethyl)-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine

(S)-6-chloro-5-(4-(3-(dimethylamino)propoxy)-2,6-difluorophenyl)-2-(pyrazin-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyrimidin-4-amine

2-pyrazin-2-yl-5-(2,4,6-trifluorophenyl)pyrimidine-4,6-diol