1-Bromo-2,3-dimethoxy-4-methylbenzene

Base Information

Chemical Name:1-Bromo-2,3-dimethoxy-4-methylbenzene
CAS No.:201471-78-5
Molecular Formula:C9H11BrO2
Molecular Weight:231.089
Hs Code.:
DSSTox Substance ID:DTXSID70496158
Wikidata:Q82344838

Synonyms:1-Bromo-2,3-dimethoxy-4-methylbenzene;201471-78-5;SCHEMBL4922559;DTXSID70496158;NQRZZKAZLGASGY-UHFFFAOYSA-N;1-Bromo-2,3-dimethoxy-4-methyl-benzene;EN300-7437291

Suppliers and Price of 1-Bromo-2,3-dimethoxy-4-methylbenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-Bromo-2,3-dimethoxy-4-methylbenzene

Chemical Property:

PSA：18.46000
LogP:2.77470
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:229.99424
Heavy Atom Count:12
Complexity:141

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=C(C=C1)Br)OC)OC

Technology Process of 1-Bromo-2,3-dimethoxy-4-methylbenzene

There total 1 articles about 1-Bromo-2,3-dimethoxy-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 4463-33-6
1,2-dimethoxy-3-methylbenzene

: 201471-78-5
1-bromo--2,3--dimethoxy-4--methylbenzene

Guidance literature:: 1,2-dimethoxy-3-methylbenzene; With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In diethyl ether; pentane; at -45 - 0 ℃; for 4.25h; Inert atmosphere;

With 1,2-dibromo-1,1,2,2-tetrachloroethane; In tetrahydrofuran; diethyl ether; pentane; at 20 ℃; for 17h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol302898h

Reference yield: 95.0%

: 201471-78-5
1-bromo--2,3--dimethoxy-4--methylbenzene

: 201471-76-3
3-bromo-6--methylbenzene-1,2--diol

Guidance literature:: 1-bromo--2,3--dimethoxy-4--methylbenzene; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 7h; Inert atmosphere;

With water; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/ol302898h

Reference yield:

: 201471-78-5
1-bromo--2,3--dimethoxy-4--methylbenzene

: 201471-97-8
4-(2,3-Dimethoxy-4-methyl-phenyl)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 9-BBN, 2) CH₃ONa / 2) dichloro<1,1'-bis(diphenylphosphino)ferrocene>palladium(II) / 1) THF, room temperature, 3 h, 2) THF, reflux, 3 h

2: 85 percent / KOH / ethanol / 4 h / Ambient temperature

With potassium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; sodium methylate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol;
DOI:10.1016/S0040-4020(97)10270-8