4-(N-BENZYLAMINO)-1-BENZYLPIPERIDINE

Base Information

• Chemical Name: 4-(N-BENZYLAMINO)-1-BENZYLPIPERIDINE
• CAS No.: 202198-91-2
• Molecular Formula: C19H24N2
• Molecular Weight: 280.413
• Mol file: 202198-91-2.mol

Synonyms:1-Benzyl-4-benzylamino-piperidin;benzyl-(1-benzyl-piperidin-4-yl)-amine;I14-7694;4-(N-BENZYLAMINO)-1-BENZYLPIPERIDINE;

Chemical Property of 4-(N-BENZYLAMINO)-1-BENZYLPIPERIDINE

Chemical Property:

• PSA: 15.27000
• LogP: 3.76960

Purity/Quality:

98% ^*data from raw suppliers

4-(N-BENZYLAMINO)-1-BENZYLPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(N-BENZYLAMINO)-1-BENZYLPIPERIDINE

There total 8 articles about 4-(N-BENZYLAMINO)-1-BENZYLPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-(1-benzylpiperidin-4-yl)-1-phenylmethanimine → N-benzylpiperidin-4-yl-benzylamine (202198-91-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 5 ℃;

DOI:10.1016/j.ejmech.2019.02.030

Reference yield:

4-aminopiperidine dihydrochloride (35621-01-3,117890-46-7) → C18H28N2 + N-benzylpiperidin-4-yl-benzylamine (202198-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / Reflux; Inert atmosphere; Dean-Stark

2: 20 °C / Inert atmosphere; Dean-Stark

With sodium carbonate;

DOI:10.1021/op049812w

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-benzylpiperidin-4-yl-benzylamine (202198-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl₄ / CH₂Cl₂ / 5 °C

2: NaBH₄ / methanol; CH₂Cl₂ / 0 - 5 °C

With sodium tetrahydroborate; titanium tetrachloride; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(02)00487-0

upstream raw materials:

1-phenylmethyl-4-piperidone

benzylamine

4-aminopiperidine dihydrochloride

benzyl chloride

Downstream raw materials:

4-amino-1-benzylpiperidine