4-Aminopiperidine dihydrochloride

Base Information

• Chemical Name: 4-Aminopiperidine dihydrochloride
• CAS No.: 35621-01-3
• Molecular Formula: C₅H₁₂N₂*2ClH
• Molecular Weight: 173.086
• Hs Code.: 29333990
• Mol file: 35621-01-3.mol

Synonyms:4-Piperidinamine,dihydrochloride (9CI);

Chemical Property of 4-Aminopiperidine dihydrochloride

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 2.57mmHg at 25°C
• Melting Point: 170-175ºC
• Boiling Point: 158.9 °C at 760 mmHg
• Flash Point: 53.4 °C
• PSA: 38.05000
• LogP: 2.33020
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

4-aminopiperidine dihydrochloride 98 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Aminopiperidine dihydrochloride

There total 1 articles about 4-Aminopiperidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → 4-aminopiperidine dihydrochloride (35621-01-3,117890-46-7)

Guidance literature:

With sulfuric acid; sodium chloride; In neat (no solvent); at 20 ℃; for 5h; Sealed tube;

DOI:10.1039/d1ob00728a

Reference yield: 87.0%

o-cyanobromobenzene (2042-37-7) + 4-aminopiperidine dihydrochloride (35621-01-3,117890-46-7) → 2-(4-piperidinylamino)benzonitrile

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 85 ℃; for 0.5h;

DOI:10.1016/S0040-4039(98)00517-6

Reference yield: 84.0%

4-bromobenzenecarbonitrile (623-00-7) + 4-aminopiperidine dihydrochloride (35621-01-3,117890-46-7) → 4-[(4-cyanophenyl)amino]piperidine (208398-34-9) + 4-(4-Amino-piperidin-1-yl)-benzonitrile (281234-90-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 85 ℃; for 0.5h; Yields of byproduct given;

DOI:10.1016/S0040-4039(98)00517-6

upstream raw materials:

(piperidin-4-yl)carbamic acid tert-butyl ester

Downstream raw materials:

N-(1-formyl-[4]piperidyl)-formamide

2,4,6-Trimethyl-N-[1-(2,4,6-trimethyl-benzenesulfonyl)-piperidin-4-yl]-benzenesulfonamide

norastemizole

4-[(4-cyanophenyl)amino]piperidine

Refernces