Recoflavone

Base Information

• Chemical Name: Recoflavone
• CAS No.: 203191-10-0
• Molecular Formula: C20H18O8
• Molecular Weight: 386.358
• UNII: U96J5LG435
• DSSTox Substance ID: DTXSID50174205
• Nikkaji Number: J3.285.252A
• Wikidata: Q27290945
• NCI Thesaurus Code: C152170
• Metabolomics Workbench ID: 153114
• ChEMBL ID: CHEMBL4297606
• Mol file: 203191-10-0.mol

Synonyms:7-carboxymethoxyloxy-3',4',5-trimethoxyflavone;DA 6034;DA-6034;recoflavone

Chemical Property of Recoflavone

Chemical Property:

• PSA: 104.43000
• LogP: 2.94920
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 386.10016753
• Heavy Atom Count: 28
• Complexity: 603

Purity/Quality:

98%min ^*data from raw suppliers

2-([2-(3,4-DIMETHOXYPHENYL)-5-METHOXY-4-OXO-4H-CHROMEN-7-YL]OXY)ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C=C3OC)OCC(=O)O)OC
• Recent ClinicalTrials: Phase I Study to Evaluate the Tolerability of Eye Drop DA-6034 in Healthy Volunteers
• Uses: Recoflavone is a synthetic flavonoid known to possess anti-inflammatory activity and also used in the treatment of gastritis.

Technology Process of Recoflavone

There total 6 articles about Recoflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-ethyloxycarbonylmethyloxy-3',4',5-trimethoxy flavone (847909-46-0) → 7-carboxymethyloxy-3',4',5-trimethoxy flavone (203191-10-0)

Guidance literature:

7-ethyloxycarbonylmethyloxy-3',4',5-trimethoxy flavone; With sodium hydroxide; In tetrahydrofuran; water; for 2h; Heating / reflux;

With hydrogenchloride; In water; at 0 - 5 ℃;

Reference yield: 95.0%

7-t-butyloxycarbonylmethyloxy-3',4',5-trimethoxy flavone (847909-43-7) → 7-carboxymethyloxy-3',4',5-trimethoxy flavone (203191-10-0)

Guidance literature:

With toluene-4-sulfonic acid; In chloroform; toluene; for 3h; Heating / reflux;

Reference yield:

7-hydroxy-6,3',4'-trimethoxyflavone (118793-57-0) → 7-carboxymethyloxy-3',4',5-trimethoxy flavone (203191-10-0)

Guidance literature:

upstream raw materials:

7-hydroxy-6,3',4'-trimethoxyflavone

7-ethyloxycarbonylmethyloxy-3',4',5-trimethoxy flavone

7-t-butyloxycarbonylmethyloxy-3',4',5-trimethoxy flavone

3',5,7-trihydroxy-4'-methoxy flavone-7-rutinoside

Downstream raw materials:

7-carboxymethyloxy-3',4',5-trimethoxy flavone monohydrate

7-{(carbamylcarbamoyl)methyloxy}-3',4',5-trimethoxyflavone

7-{(formylcarbamoyl)methyloxy}-3',4',5-trimethoxyflavone

7-{(N-cyanocarbamoyl)-methyloxy}-3',4',5-trimethoxyflavone