Oxane-4-thiol

Base Information

Chemical Name:Oxane-4-thiol
CAS No.:203246-71-3
Molecular Formula:C5H10OS
Molecular Weight:118.2
Hs Code.:2932999099
European Community (EC) Number:805-478-1
DSSTox Substance ID:DTXSID50594868
Wikidata:Q82489780
Mol file:203246-71-3.mol

Synonyms:oxane-4-thiol;203246-71-3;tetrahydro-2H-pyran-4-thiol;Tetrahydro-pyran-4-thiol;tetrahydropyran-4-thiol;2H-Pyran-4-thiol, tetrahydro-;MFCD12088024;SCHEMBL601190;DTXSID50594868;HDEOKHIQTDMWTQ-UHFFFAOYSA-N;AKOS009625072;AT12453;AM100476;BS-12727;SY181133;EN300-56364;A24390;J-013215

Suppliers and Price of Oxane-4-thiol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tetrahydropyran-4-thiol
1g
$ 1320.00

Medical Isotopes, Inc.
Tetrahydropyran-4-thiol
100 mg
$ 650.00

Medical Isotopes, Inc.
Tetrahydropyran-4-thiol
1 g
$ 2200.00

Matrix Scientific
Tetrahydro-2H-pyran-4-thiol 97%
10g
$ 4608.00

Matrix Scientific
Tetrahydro-2H-pyran-4-thiol 97%
5g
$ 2880.00

Chemenu
tetrahydro-2H-pyran-4-thiol 95%
1g
$ 533.00

American Custom Chemicals Corporation
OXANE-4-THIOL 95.00%
5G
$ 1928.08

American Custom Chemicals Corporation
OXANE-4-THIOL 95.00%
2.5G
$ 1473.14

American Custom Chemicals Corporation
OXANE-4-THIOL 95.00%
1G
$ 983.52

AK Scientific
Oxane-4-thiol
250mg
$ 442.00

Total 8 raw suppliers

Chemical Property of Oxane-4-thiol

Chemical Property:

Vapor Pressure:1.59mmHg at 25°C
Boiling Point:174.8oC at 760 mmHg
Flash Point:59.5oC
PSA：48.03000
Density:1.03g/cm3
LogP:1.09520
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:118.04523611
Heavy Atom Count:7
Complexity:50

Purity/Quality:

97% ^*data from raw suppliers

Tetrahydropyran-4-thiol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCC1S
Uses Tetrahydropyran-4-thiol is a building block for various pharmaceutical goods such as MDM2 inhibitors for the treatment of cancer.

Technology Process of Oxane-4-thiol

There total 4 articles about Oxane-4-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 203246-70-2
thioacetic acid S-(tetrahydro-pyran-4-yl)ester

: 203246-71-3
tetrahydro-2H-pyran-4-thiol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1002/anie.201910436

Reference yield:

: tetrahydro-thiopyran-4-one

: 203246-71-3
tetrahydro-2H-pyran-4-thiol

Guidance literature:: With sodium tetrahydroborate; ethanol; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 203246-71-3
tetrahydro-2H-pyran-4-thiol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen sulfide / isopropyl alcohol / 4 h / 0 - 5 °C

2: ethanol; sodium tetrahydroborate / 2 h / 80 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; hydrogen sulfide; In isopropyl alcohol;