N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

Base Information

Chemical Name:N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide
CAS No.:1453173-84-6
Molecular Formula:C₂₀H₂₀N₂O₅S
Molecular Weight:400.455
Hs Code.:

Synonyms:N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

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Chemical Property of N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

Chemical Property:

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Technology Process of N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

There total 12 articles about N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272855-55-6
4-(tetrahydropyran-4-ylsulfanyl)benzonitrile

: 112372-15-3
furo<2,3-c>pyridine-2-carboxylic acid

: 1453173-84-6
N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1450723-81-5
C₁₂H₁₇NO₃S

: 112372-15-3
furo<2,3-c>pyridine-2-carboxylic acid

: 1453173-84-6
N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1016/j.bmcl.2014.12.026

Reference yield:

: 18343-02-7
Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate

: 1453173-84-6
N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]furo[2,3-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 16 h / 0 - 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 16 h / 0 - 20 °C

3: palladium 10% on activated carbon; triethylamine; hydrogen / ethanol / 16 h / 760.05 Torr

4: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With pyridine; palladium 10% on activated carbon; water; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;