(6,7-Dimethoxy-3,4-dihydro-1-isoquinolinyl)(3,4-dimethoxyphenyl)methanone

Base Information

• Chemical Name: (6,7-Dimethoxy-3,4-dihydro-1-isoquinolinyl)(3,4-dimethoxyphenyl)methanone
• CAS No.: 20345-69-1
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• DSSTox Substance ID: DTXSID801347053
• Nikkaji Number: J469.918A
• ChEMBL ID: CHEMBL2442088

Synonyms:20345-69-1;(6,7-Dimethoxy-3,4-dihydro-1-isoquinolinyl)(3,4-dimethoxyphenyl)methanone;(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone;(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)-(3,4-dimethoxyphenyl)methanone;Oprea1_035865;CHEMBL2442088;DTXSID801347053;STK678197;AKOS000277064;CS-0357295;EU-0086387;SR-01000537039;SR-01000537039-1;1-(3,4-Dimethoxybenzoyl)-3,4-dihydro-6,7-dimethoxyisoquinoline

Chemical Property of (6,7-Dimethoxy-3,4-dihydro-1-isoquinolinyl)(3,4-dimethoxyphenyl)methanone

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 355.14197277
• Heavy Atom Count: 26
• Complexity: 522

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)C2=NCCC3=CC(=C(C=C32)OC)OC)OC

Technology Process of (6,7-Dimethoxy-3,4-dihydro-1-isoquinolinyl)(3,4-dimethoxyphenyl)methanone

There total 26 articles about (6,7-Dimethoxy-3,4-dihydro-1-isoquinolinyl)(3,4-dimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide (139-76-4) → 3,4-dihydropapaverine (6957-27-3) + 3,4-dihydropapaveraldine (20345-69-1)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 1h;

DOI:10.1134/S1070428020070258

Reference yield: 90.0%

3,4-dihydropapaverine (6957-27-3) → 3,4-dihydropapaveraldine (20345-69-1)

Guidance literature:

With oxygen; In ethyl acetate; at 20 ℃; for 10h;

DOI:10.1002/cjoc.201400471

Reference yield: 85.0%

Tetrahydropapaverine (13074-31-2) → Papaverine (58-74-2) + 3,4-dihydropapaveraldine (20345-69-1)

Guidance literature:

With diphenylselenium bis(trifluoroacetate); In 1,2-dimethoxyethane; Ambient temperature;

DOI:10.1021/ja00405a087

upstream raw materials:

N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide

ethanol

3,4-dihydropapaverine

1,2,3,4-tetrahydro-6,7-dimethoxy-2-(3,4-dimethoxybenzyl)isoquinoline

Downstream raw materials:

2-benzoyl-1-cyano-6,7-dimethoxy-1-(3',4'-dimethoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline

(6,7-dimethoxy-3,4-dihydro-isoquinolin-1-yl)-(3-hydroxy-4-methoxy-phenyl)-methanone

(7-Hydroxy-6-methoxy-3,4-dihydro-isoquinolin-1-yl)-(3-hydroxy-4-methoxy-phenyl)-methanone

(3,4-Dimethoxy-phenyl)-(7-hydroxy-6-methoxy-3,4-dihydro-isoquinolin-1-yl)-methanone

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