N-[2-(2-Formyl-4,5-dimethoxyphenyl)ethyl]acetamide

Base Information

• Chemical Name: N-[2-(2-Formyl-4,5-dimethoxyphenyl)ethyl]acetamide
• CAS No.: 203806-36-4
• Molecular Formula: C13H17NO4
• Molecular Weight: 251.282
• DSSTox Substance ID: DTXSID70572224
• Nikkaji Number: J1.579.774F
• Wikidata: Q82460510
• Mol file: 203806-36-4.mol

Synonyms:N-[2-(2-Formyl-4,5-dimethoxyphenyl)ethyl]acetamide;203806-36-4;DTXSID70572224

Chemical Property of N-[2-(2-Formyl-4,5-dimethoxyphenyl)ethyl]acetamide

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 251.11575802
• Heavy Atom Count: 18
• Complexity: 282

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCCC1=CC(=C(C=C1C=O)OC)OC

Technology Process of N-[2-(2-Formyl-4,5-dimethoxyphenyl)ethyl]acetamide

There total 2 articles about N-[2-(2-Formyl-4,5-dimethoxyphenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6,7-dimethoxy-3,4-dihydro-isoquinoline (3382-18-1) + acetyl chloride (75-36-5) → N-[2-(2-formyl-4,5-dimethoxy-phenyl)-ethyl]-acetamide (203806-36-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1055/s-1998-2011

Reference yield:

3,4-dihydro-6,7-dimethoxyisoquinoline hydrochloride (20232-39-7) + acetyl chloride (75-36-5) → N-[2-(2-formyl-4,5-dimethoxy-phenyl)-ethyl]-acetamide (203806-36-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;

DOI:10.3987/com-02-s9

Reference yield: 60.0%

N-[2-(2-formyl-4,5-dimethoxy-phenyl)-ethyl]-acetamide (203806-36-4) + diazomethyl-trimethyl-silane (18107-18-1) → N-[2-(4,5-dimethoxy-2-vinylphenyl)ethyl]acetamide (203806-37-5)

Guidance literature:

With Rh(PPh₃)3Cl; triphenylphosphine; In tetrahydrofuran; isopropyl alcohol; at 25 ℃; for 0.5h;

DOI:10.1002/1521-3773(20010803)40:15<2887::AID-ANIE2887>3.0.CO;2-Q

upstream raw materials:

6,7-dimethoxy-3,4-dihydro-isoquinoline

acetyl chloride

3,4-dihydro-6,7-dimethoxyisoquinoline hydrochloride

Downstream raw materials:

N-[2-(4,5-dimethoxy-2-vinylphenyl)ethyl]acetamide

N-(tert-butoxycarbonyl)-2-(4,5-dimethoxy-2-vinylphenyl)ethylamine

N-(tert-Butoxycarbonyl)-N-[2-(4,5-dimethoxy-2-vinylphenyl)ethyl]acetamide

ethyl (E)-3-(2-(2-acetamidoethyl)-4,5-dimethoxyphenyl)acrylate